热休克蛋白90在胃肠道肿瘤诊断中的价值  

Heat shock protein 90 in the diagnosis of gastrointestinal tumors

作　　者：项明伟 郭闻一[1] 邓文宏[1] 何小波[1] 王卫星[1] 

机构地区：[1]武汉大学人民医院普外科,430060

出　　处：《中华普通外科杂志》2017年第5期442-444,共3页Chinese Journal of General Surgery

摘　　要：目的探讨热休克蛋白90（heat shock protein90，HSP00）在胃肠道肿瘤诊断与分期和分型中的意义。方法选取2014年1月至2015年4月期间在武汉大学人民医院就诊的518例胃肠道肿瘤患者，检测其血清HSP90水平。结果肿瘤组患者血清HSP90水平（112±74）ng／ml高于对照组，ROC曲线下面积为0．875，诊断临界值为63．63，对应敏感度为76．1％．特异度为92．6％。胃癌组患者血清HSP90水平为（135±73）ng／ml，结肠癌组为（105±60）ng／ml，直肠癌组为（79±42）mg／ml，3组相比差异有统计学意义（P〈0．05）；中、低分化腺癌组比高分化腺癌组HSP90水平升高（P〈0．05）；肿瘤浸润至黏膜层以下和浆膜层后，血清HSP90升高（P〈0．05）；淋巴结转移组患者血清HSP90高于无淋巴结转移组（P〈0．05）。结论胃肠道肿瘤患者血清HSP90水平具有较高的诊断价值，并且与肿瘤分化程度及浸润情况有关。Objective To evaluate HSP90 levels in the diagnosis and staging of gastrointestinal tumors. Method Patients with gastrointestinal tumors hospitalized from 2014 January to 2015 April were enrolled in this study. Serum level of HSP90 was detected. Results The serum HSP90 level of cancer group （112 ± 74）was significantly higher than the control groups, the area under the ROC curve of HSP90＇s was 0. 875 and the cut-off point was 63.63 with sensitivity of 76. 1% and specificity of 92. 6%. The HSP90 level in gastric cancer group（ 135 ±73） ng/ml was the highest, in colon cancer group was （105±60） ng/ml and in rectum cancer group was（ 79 ± 42）ng/ml （all P 〈 0. 05 ）. Serum HSP90 levels in moderate and low differentiated adenocarcinoma were higher than well differentiated adenocarcinoma group （ P 〈 0. 05 ）. Serum HSP90 level was higher in tumors with submucosa and serosa infiltration （ P 〈 0. 05 ）. Those with lymphatic metastasis tend to have a higher serum HSP90 level than those without. Conclusion Serum HSP90 level has a good predictive value on gastrointestinal tumor diagnosis, and it is correlated with tumor staging and infiltration status.

关 键 词：胃肠肿瘤 HSP90热休克蛋白质类 血清学试验 

分 类 号：R735[医药卫生—肿瘤]