Association of ADIPOQ and ADIPOR Variants with Risk of Colorectal Cancer：A Meta-analysis  

作　　者：谭璇 王国斌 唐勇 白洁 叶霖 

机构地区：[1]Department of Ophthalmology, Union Hospital, Tongii Medical College, Huazhong University of Science and Technology,Wuhan 430022, China [2]Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science andTechnology, Wuhan 430022, China

出　　处：《Journal of Huazhong University of Science and Technology(Medical Sciences)》2017年第2期161-171,共11页华中科技大学学报（医学英德文版）

基　　金：supported by National Natural Science Foundation of China(No.81301691);the first Young Talents Foundation of Hubei Province(No.2014);Hubei Province Health and Family Planning Scientific Research Project(No.WJ2017Q023 and No.WJ2017M113);the Fundamental Research Funds for the Central Universities(No.2015LC029);Natural Science Foundation of Hubei Province(No.2016CFB356)

摘　　要：Numerous epidemiological studies have studied the association of adiponectin（ADIPOQ） gene and adiponectin receptor（ADIPOR） gene polymorphisms with risk of colorectal cancer（CRC）,but the outcomes were incomplete and inconsistent.Therefore,we conducted a meta-analysis to assess the associations systematically.All eligible case-control studies published up to Jan.2015 were searched from Pub Med,the Cochrane library,Elsevier,Wiley Online library,China National Knowledge Infrastructure,Wan Fang data and Chongqing VIP.Effect sizes of odds ratio（OR） and 95% confidence interval（95%CI） were calculated by using a fixed-or random-effect model.Twelve case-control studies including 6141 cases and 7398 controls were selected.Significant differences in the distributions of allele frequency with CRC risk were directly present in ADIPOQ variants rs2241766,rs1501299 and ADIPOR variant rs1342387.In stratified analysis for different populations,significant differences were present in ADIPOQ variant rs822396 for Ashkenazi Jewish,in ADIPOQ variant rs1501299 and ADIPOR variant rs1342387 for Chinese and in ADIPOQ variant rs 2241766 for Ashkenazi Jewish and Chinese.In addition,the factors correlated with insulin resistance had synergistic effect with ADIPOQ variants rs2241766 T/G and rs1501299 G/T on risk of CRC.ADIPOQ variants rs2241766 T/G,rs1501299 G/T and ADIPOR variant ADIPOR rs1342387 G/A had a population specific correlation with CRC risk,which may be mediated by insulin resistance.And large well-designed studies are still needed for further evaluation of rs822396 and rs1063538,especially for their interaction and combined effect in the correlation with CRC risk.Numerous epidemiological studies have studied the association of adiponectin（ADIPOQ） gene and adiponectin receptor（ADIPOR） gene polymorphisms with risk of colorectal cancer（CRC）,but the outcomes were incomplete and inconsistent.Therefore,we conducted a meta-analysis to assess the associations systematically.All eligible case-control studies published up to Jan.2015 were searched from Pub Med,the Cochrane library,Elsevier,Wiley Online library,China National Knowledge Infrastructure,Wan Fang data and Chongqing VIP.Effect sizes of odds ratio（OR） and 95% confidence interval（95%CI） were calculated by using a fixed-or random-effect model.Twelve case-control studies including 6141 cases and 7398 controls were selected.Significant differences in the distributions of allele frequency with CRC risk were directly present in ADIPOQ variants rs2241766,rs1501299 and ADIPOR variant rs1342387.In stratified analysis for different populations,significant differences were present in ADIPOQ variant rs822396 for Ashkenazi Jewish,in ADIPOQ variant rs1501299 and ADIPOR variant rs1342387 for Chinese and in ADIPOQ variant rs 2241766 for Ashkenazi Jewish and Chinese.In addition,the factors correlated with insulin resistance had synergistic effect with ADIPOQ variants rs2241766 T/G and rs1501299 G/T on risk of CRC.ADIPOQ variants rs2241766 T/G,rs1501299 G/T and ADIPOR variant ADIPOR rs1342387 G/A had a population specific correlation with CRC risk,which may be mediated by insulin resistance.And large well-designed studies are still needed for further evaluation of rs822396 and rs1063538,especially for their interaction and combined effect in the correlation with CRC risk.

关 键 词：adiponectin gene adiponectin receptor gene single nucleotide polymorphisms colorectal cancer 

分 类 号：R735.34[医药卫生—肿瘤]