丙氨酰-谷氨酰胺联合乌司他丁与生长抑素治疗急性重症胰腺炎临床疗效评价  

Clinical curative effect evaluation of alanyl-glutamine combined with ulinastatin and somatostatin in treatment of severe acute pancreatitis

作　　者：朱春霞[1] 陆蓉丹 胡桂梅[1] 吕雪幼 冯雪峰[2] 汪建华[3] 

机构地区：[1]宁波大学医学院附属医院消化内科,浙江宁波315020 [2]宁波大学医学院附属医院肝胆外科,浙江宁波315020 [3]宁波大学医学院附属医院影像科,浙江宁波315020

出　　处：《中国现代医生》2017年第13期95-98,共4页China Modern Doctor

基　　金：浙江省医药卫生科技计划项目(2012KYB176)

摘　　要：目的观察并评估丙氨酰-谷氨酰胺联合乌司他丁与生长抑素治疗急性重症胰腺炎(SAP)的临床治疗效果。方法选取2014年1月~2016年6月期间宁波大学医学院附属医院收治的86例急性重症胰腺炎患者,依据随机数字表法分为研究组和对照组,每组各43例。对照组患者采用乌司他丁+生长抑素方案治疗,而研究组患者在此基础上加用丙氨酰-谷氨酰胺,静脉滴注0.4 g/kg,评估并比较两组患者的临床治疗效果。结果经治疗,研究组获得95.35%的临床总疗效,显著高于对照组的81.40%,差异具有统计学意义(P<0.05)。研究组患者腹痛缓解时间、肠功能恢复时间、血淀粉酶恢复正常时间及平均住院日均显著短于对照组;治疗后研究组患者血C反应蛋白(CRP)、白细胞介素-8(IL-8)及肿瘤坏死因子-α(TNF-α)水平均显著低于对照组。结论丙氨酰-谷氨酰胺联合乌司他丁与生长抑素是治疗急性重症胰腺炎的有效方法,可有效缓解临床症状,提高临床疗效,改善患者预后。Objective To observe and evaluate the therapeutic effects of alanyl-glutamine combined with ulinastatin and somatostatin in treatment of severe acute pancreatitis （SAP）. Methods Eighty-six patients with SAP were selected from January 2014 to June 2016 admitted to the Affiliated Hospital of Ningbo University School of Medicine. They were divided into research group （n=43） and control group （n=43） according to the random number table. The patients of the control group received the routine therapy of ulinastatin and somatostatin while the research group received an addition- al treatment of alanyl-glutamine, intravenous infusion by 0.4 g/kg, then the clinical therapeutic effect of the two groups was evaluated and compared. Results After treatment, clinical total curative effect of the research group was 95.35%, which was significantly higher than the control group of 81.40%, the difference was statistically significant（P〈0.05）. The recovery time of abdominal pain, bowel function, blood urinary amylase and average hospitalized time in research group were significantly shorter than those in control group. Levels of C reactive protein（CRP）, interleukin-8（IL-8）, tumor necrosis factor-α（TNF-α） in research group after treatment were significantly lower than those in control group. Conclusion Alanyl-glutamine combined with ulinastatin and somatostatin is an effective method in treating SAP, which can effectively relieve clinical symptoms, improve clinical effect and prognosis of patients.

关 键 词：丙氨酰-谷氨酰胺 乌司他丁 生长抑素 急性重症胰腺炎 

分 类 号：R576[医药卫生—消化系统]