合并脊髓空洞的视神经脊髓炎谱系疾病1例报告并文献复习  

Neuromyelitis optica spectrum disorder combined with syringomyelia:A case report and literature review

作　　者：伍楚君 张晖[1] 任海涛[2] 樊东升[1] 王丽平[1] 

机构地区：[1]北京大学第三医院神经内科,100191 [2]北京协和医院北京协和医学院神经内科

出　　处：《北京医学》2017年第5期479-482,共4页Beijing Medical Journal

摘　　要：目的总结合并脊髓空洞的视神经脊髓炎谱系疾病(neuromyelitis optica spectrum disorders,NMOSD)的特点。方法针对1例收住我院且确诊为NMOSD的患者进行多次病灶部位影像学检查,同时复习相关文献。结果该例患者颈髓病灶内可见以中央管为中心的、分隔的、形态不规则但边界相对清楚的空洞形成,空洞随患者病情缓解逐渐缩小。结论 NMOSD可合并脊髓空洞形成,空洞形态多不规则,周围存在炎性病变且可有斑片状强化,与炎性脱髓鞘病灶存在时间和空间的相关性,在急性期出现,缓解期可自行缩小或消失。Objective To summarize the characteristics of neuromyelitis optica spectrum disorder（NMOSD） combined with syringomyelia. Methods The medical records and spinal cord magnetic resonance imaging（MRI） of patients with NMOSD were collected. The follow-up neuro-imaging study was also evaluated. Meanwhile, the relevant literatures were reviewed. Results Separated, irregular but well defined syringomyelia had formed in the cervical spinal cord around the central canal, which had shrunk gradually with disease remission. Conclusion NMOSD can be accompanied with syringomyelia formation, which is characterized by irregular shapes and surrounding inflammation. There is a close time and spatial correlation between syringomyelia and inflammation lesions in NMOSD. Syringomyelia in NMOSD is obvious in acute phase and has shrunk gradually with disease remission.

关 键 词：视神经脊髓炎谱系疾病 脊髓空洞症 水通道蛋白4抗体 

分 类 号：R744.52[医药卫生—神经病学与精神病学]