化疗对肠道菌群及血清5-羟色胺水平的影响  

Effect of chemotherapy on intestinal microbiota and serum 5-HT level

作　　者：董为为 唐艳[1] 丛丽敏 邓英[1] 朱学良 李明[1] 袁杰利[1] 

机构地区：[1]大连医科大学微生态教研室,辽宁大连116044 [2]武汉百信正源生物技术工程有限公司,湖北武汉430010

出　　处：《中国微生态学杂志》2017年第5期615-618,共4页Chinese Journal of Microecology

基　　金：国家863项目临床营养菌种资源库的研发及应用(2014AA022209)

摘　　要：化疗不仅导致肠黏膜炎和5-羟色胺(5-HT)水平的异常,也会诱发肠道菌群失衡。平衡状态下的微生物是一道生物屏障,菌群失衡可加剧肠道炎症。近期研究发现,5-HT的水平受肠道菌群的调节。因此,化疗引起的5-HT水平改变可能与肠道菌群的异常有关。本研究主要探讨肠道菌群通过何种途径影响化疗后肠黏膜炎和5-HT水平,为临床上以益生菌调节肠道菌群来改善化疗后的胃肠道反应提供依据。Chemotherapy induces not only intestinal mucositis and abnormal 5-HT level, but also dysbiosis of intestinal microbiota. Intestinal microbiota in a state of equilibrium act as a biological barrier, while the imbalance of gut microbiota can exacerbate gut mucosal inflammation. Recent research found that the level of 5-HT is regulated by the gut mierobiota. Therefore, abnormal level of 5-HT may be related to the changes of gut microbiota caused by chemotherapy. This paper mainly discusses the ways in which gut bacteria affect chemotherapy induced mucositis and 5-HT level, in order to provide theoretical basis for the regulation of gut microbiota and remission of chemotherapy induced gastrointestinal reactions with probiotics.

关 键 词：化疗 肠黏膜炎 5-HT 肠道菌群 

分 类 号：R730.53[医药卫生—肿瘤]