脑梗塞检测中栓溶二聚体的应用价值及分析  

Value of D-dimer in evaluation of cerebral infarction

作　　者：刘启波[1] 苗霞[1] 周兵[1] 李蔼文[1] Liu Qibo Miao Xia Zhou Bing Li Aiwen(Department o,f Clinical Laboratory, Guangdong Second Provincial Hospital, Guangzhou 510095, Guangdong, China)

机构地区：[1]广东省第二中医院检验科,广东广州510095

出　　处：《广州医科大学学报》2016年第6期12-15,共4页Academic Journal of Guangzhou Medical University

摘　　要：目的:分析脑梗塞患者诊疗工作中溶栓二聚体(D-dimer,D-D)指标测定方式及临床意义。方法:选取我院收治的脑血管病患者,其中脑梗塞75例、脑出血30例、脑供血不全12例,及健康对照组65例,测定分析患者血浆D-D阳性率及D-D半定量检测水平。结果:脑出血患者血浆D-D阳性率(56.7%)、脑梗塞血浆D-D阳性率(53.3%)、脑供血不全患者血浆D-D阳性率(41.7%)均显著高于对照组(P<0.05),而3组脑血管疾病患者组间血浆D-D阳性率无差异(P>0.05)。脑出血患者血浆D-D水平为(1013.5±110.2)μg/L、脑出血组患者血浆D-D水平为(877.4±49.5)μg/L、脑供血不全组患者血浆D-D水平为(701.2±98.5)μg/L,血浆D-D半定量结果均显著高于对照组(P<0.05),而3组脑血管疾病患者组间血浆D-D半定量结果无差异(P>0.05)。结论:脑梗塞患者血浆D-D阳性率及半定量浓度水平均较健康人群偏高,但与其他脑血管疾病患者测定结果没有明显差别,临床上可借助该指标开展诊疗工作。Objective：To investigate the level and clinical significance of D-dimer（D-D） detected with two methods in patients with cerebral infarction.Methods：75 patients with cerebrovascular diseases treated in our hospital were recruited in this study,comprising 30 patients with cerebral hemorrhage,and 12 patients with cerebral vascular insufficiency.A control group of 65 healthy subjects was set.All groups were determined for positive rate of plasma D-D and underwent semi-quantitative detection of plasma D-D level.Results：The positive rates of plasma D-D were,respectively,56.7%in patients with cerebral hemorrhage,53.3%in patients with cerebral infarction,and 41.7%in patients with cerebral vascular insufficiency.The positive rate of plasma D-D in these three groups was significantly higher than that in the control group（P〈0.05）but was not significantly different among the three groups of patients（P〉0.05）.The plasma D-D levels were,respectively,（1 013.5＆#177;110.2）μg/L in patients with cerebral hemorrhage,（877.4＆#177;49.5） μg/L in patients with cerebral infarction,and（701.2＆#177;98.5） μg/L in patients with cerebral vascular insufficiency.The plasma D-D levels as detected D-D with semi-quantitative assay were significantly higher in the three patients groups than that in the control group（P〈0.05）,but did not significantly differ among the three patient groups（P〉0.05）.Conclusion：The plasma D-D positive rate and level inpatients with cerebral infarction were higher than those in healthy subjects,but do not differ significantly from those in patients with other cerebrovascular diseases.Clinically,plasma DD can be as an indicator in diagnosis and treatment of the disease.

关 键 词：脑梗塞 溶栓二聚体 检测 价值 

分 类 号：R743.3[医药卫生—神经病学与精神病学]