瑞舒伐他汀治疗急性脑梗死的疗效及对血脂、hs-CRP及颈动脉粥样硬化斑块的影响  

Effect of rosuvastatin on patients with acute cerebral infarction and its effect on blood lipid, hs-CRP and carotid atherosclerotic plaque

作　　者：杜迎春[1] 

机构地区：[1]河南省平顶山市第一人民医院神经内三科,467000

出　　处：《中国实用医刊》2017年第9期36-40,共5页Chinese Journal of Practical Medicine

摘　　要：目的 探讨瑞舒伐他汀治疗急性脑梗死患者的疗效及对其血脂、超敏C-反应蛋白（hs-CRP）及颈动脉粥样硬化斑块的影响.方法 选取2014年8月至2016年2月符合研究选取标准的104例急性脑梗死患者,根据入院先后顺序不同分为研究组与对照组,每组52例.对照组以常规治疗措施进行治疗,研究组在对照组治疗基础上加用瑞舒伐他汀.对比治疗前后两组血脂相关指标[三酰甘油（TG）、总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）]及hs-CRP水平、颈动脉内膜中层厚度（IMT）变化情况,并统计两组颈动脉粥样硬化情况、颈动脉狭窄情况及不稳定斑块检出情况.结果 治疗前两组TC、TG、LDL-C、HDL-C、hs-CRP、左右两侧IMT水平比较差异未见统计学意义（P〉0.05）;治疗后,研究组明显优于对照组,差异有统计学意义（P〈0.05）.研究组轻度颈动脉粥样硬化发生率（53.85%）、轻度颈动脉狭窄发生率（57.69%）明显高于对照组（34.62%、26.54%）,差异有统计学意义（P〈0.05）.两组中重度颈动脉粥样硬化发生率、中重度颈动脉狭窄发生率比较差异未见统计学意义（P〉0.05）;研究组不稳定斑块检出率（59.62%）明显低于对照组（80.77%）,差异有统计学意义（P〈0.05）.结论 采用瑞舒伐他汀治疗急性脑梗死患者疗效确切,可有效改善血脂相关指标水平,减轻炎性反应,同时可稳定及逆转动脉粥样硬化斑块,具有推广价值.Objective To investigate the effect of rosuvastatin on patients with acute cerebral infarction and its effect on blood lipid, high sensitive C-reactive protein and carotid atherosclerotic plaque.Methods One hundred and four patients with acute cerebral infarction were selected from August 2014 to February 2016.According to the order of admission, the patients were divided into study group and control group, with 52 cases in each group.The control group was treated by routine treatment, and the study group was treated by the conventional therapy based on the use of rosuvastatin.The triglyceride （TG）, total cholesterol （TC）, high density lipoprotein cholesterol （HDL-C）, low density lipoprotein cholesterol （LDL-C） and hs-CRP levels and carotid artery intima-media thickness （IMT） changes between the two groups before and after treatment were compared, and the carotid atherosclerosis, carotid artery stenosis and unstable plaques detection were analyzed between the two groups.Results The TC, TG, LDL-C, HDL-C, hs CRP, the IMT levels of both sides had no significant difference between the two groups before treatment （P〉0.05）.After treatment, all indexes in the study group were significantly better than those in the control group, the differences were significant （P〈0.05）.The mild carotid atherosclerosis incidence （53.85%） and mild carotid stenosis incidence （57.69%） in study group were significantly higher than those in the control group （34.62%, 26.54%）, the differences were significant （P〈0.05）.The severe carotid atherosclerosis occurrence rate and the severe carotid artery stenosis rate had no significant difference between the two groups （P〉0.05）.The detection rate of unstable plaque in the study group （59.62%） was significantly lower than that in the control group （80.77%）, and the difference was significant （P〈0.05）.Conclusions The effect of rosuvastatin on acute cerebral infarction is good, it can effectively improve the blood lipid level of rel

关 键 词：瑞舒伐他汀 急性脑梗死 血脂 超敏C-反应蛋白 颈动脉粥样硬化斑块 

分 类 号：R743.33[医药卫生—神经病学与精神病学]