叶酸、甲钴胺对脑血管病患者同型半胱氨酸水平及认知障碍疗效观察  

Observation on the Effects of Folic Acid and Mecobalamin on Homocysteine Levels and Cognitive Impairment of Patients with Cerebrovascular Disease

作　　者：李研[1] 张艳丽[1] 孙瑞坦[1] 罗斯文 丁红[1] 朴翔宇[1] 

机构地区：[1]大连大学附属中山医院神经内一科,辽宁大连116000

出　　处：《现代生物医学进展》2017年第17期3299-3301,共3页Progress in Modern Biomedicine

基　　金：辽宁省科技厅科学技术计划项目(2012225021)

摘　　要：目的:探讨叶酸、甲钴胺对脑血管病患者血清同型半胱氨酸水平、以及认知障碍的疗效。方法:112例脑血管病患者,用随机表法,将患者分为三个叶酸组、甲钴胺组和联合治疗(叶酸+甲钴胺)组。叶酸组口服叶酸5 mg(1次/天)。甲钴胺组予以甲钴胺口服500μg(3次/天)。联合治疗组联合用药,连续口服6个月。评价治疗前后的血清同型半胱氨酸及认知障碍评分。结果:治疗后,三组间血清同型半胱氨酸水平差异有统计学意义(P<0.05)。联合治疗组血清同型半胱氨酸水平明显低于叶酸组和甲钴胺组(P<0.05)。三组间认知障碍MMSE评分差异有统计学意义(P<0.05)。甲钴胺组和联合治疗组治疗前后MMSE评分差异有统计意义(P<0.05),但叶酸组治疗前后MMSE评分差异无统计学意义(P>0.05)。联合治疗组认知障碍MMSE评分水平水平明显高于叶酸组和甲钴胺组(P<0.05)。结论:叶酸联合甲钴胺能够改善脑血管病患者认知障碍评分,降低血清同型半胱氨酸水平,但叶酸对认知障碍无明显疗效。Objective： To study the curative effects of folio acid, mecobalamin on serum homocysteine levels and cognitive im- pairment of cerebrovascular patients. Methods： A total of 112 patients with cerebrovascular disease in our hospital were randomly divided into three groups, namely, folic acid group, mecobalamin group and combination group （folio acid ＋ mecobalamin）. Patients in folio acid group had oral folio acid 5 mg once per day. Patients in meeobalamin group had mecobalamine orally 500 μg （3 times/day）. Patients in combination group had the combination of two. All had treatment for 6 consecutive months. The evaluation on serum homocysteine levels and cognitive impairment scores were carried out before and after treatment. Results： After treatment, the serum homocysteine levels had significant differences between the three groups （P〈0.05）. The serum homocysteine levels in combination group were significantly lower than in the folic acid group and mecobalamin group （P〈0.05）. The cognitive impairment MMSE score also showed statistically significant difference between three groups （P〈0.05）. The MMSE score had statistical differences between before and after treatment in mecobalamin group and combination group （P〈0.05）, but no statistical difference in MMSE score was found between before and after treatment in folio acid group （P〉0.05）. The cognitive impairment MMSE score in combination group was obviously higher than in folio acid group and mecobalamin group （P〈0.05）. Conclusions： Folio acid combined with mecobalarnin can reduce serum homocysteine levels, and improve cognitive impairment score in patients with cerebrovascular disease. But folio acid had no obvious curative effects on cognitive impairment.

关 键 词：脑血管病 叶酸 甲钴胺 认知障碍 同型半胱氨酸 

分 类 号：R743[医药卫生—神经病学与精神病学]