维生素E与左乙拉西坦对癫痫患者的临床疗效及血浆T-Aoc,MDA水平的影响  

Clinical Efficacy of Vitamin E Combined with Levetiracetam in the Treatment of Patients with Epilepsy and Its Effect on the Serum T-Aoc and MDA Levels

作　　者：王沙沙[1] 任士卿[2] 王晓静[1] 吕志坤[1] 卢波[1] 李国珍[1] 

机构地区：[1]保定市第二中心医院神经内科,河北保定072750 [2]河北医科大学附属第三医院神经内科,河北石家庄050031

出　　处：《现代生物医学进展》2017年第17期3351-3354,共4页Progress in Modern Biomedicine

基　　金：河北省卫生和计生委科研项目(20160279)

摘　　要：目的:探讨维生素E(VE)辅助左乙拉西坦(LEV)治疗癫痫的临床疗效及对患者血浆总抗氧化能力(T-Aoc)、丙二醛(MDA)水平的影响。方法:选取我院2013年6月~2015年9月收治的134例癫痫患者,随机分为两组。对照组予LEV治疗,观察组在此基础上给予VE治疗。记录比较两组临床疗效,治疗前后脑电图背景活动,血浆T-Aoc、MDA水平;并评价两组用药的安全性。结果:观察组总有效率为88.1%,较对照组(74.6%)明显升高(P<0.05)。与治疗前相比,两组治疗后脑电图指标δ、θ波频率均明显增快(P<0.05);α波频率均明显减慢(P<0.05),且观察组治疗后脑电图指标改善效果均明显优于同期对照组(P<0.05)。与治疗前比较,观察组血浆T-Aoc水平显著升高、MDA水平显著降低(P<0.01),而对照组血浆T-Aoc水平有所上升、MDA水平略有下降,但差异无统计学意义(P>0.05)。观察组不良反应发生率为10.4%,与对照组(7.5%)相比差异无统计学意义(P>0.05)。结论:VE辅助LEV治疗癫痫能更有效降低发作频率,改善脑电图背景活动,平衡机体氧化/抗氧化系统,且安全性高。Objective： To investigate the clinical effect of vitamin E （VE） and levetiracetam （LEV） on the epilepsy and serum levels of total antioxidant capacity （T-Aoc） and malondialdehyde （MDA） of patients. Methods： 134 cases with epilepsy who were treated in our hospital from June 2013 to September 2015 were selected and randomly divided into two groups. The patients in the control group were treated with LEV, while the patients in the observation group were treated with vitamin E on the basis of the control group. Then the clinical efficacy, the EEG background activity, plasma levels of T-Aoc and MDA of two groups were recorded and compared before and after the treatment, and the safety of treatment was also evaluated. Results： After the treatment, the total effective rate of observation group was 88.1%, which was higher than 74.6% in the control group （P〈0.05）. Compared with before treatment, the frequency of 8 wave, and the 0 wave of EEG in the two groups were increased, while the α wave frequency was decreased （P〈0.05）. After treatment, the improvement of EEG in the observation group was significantly better than that of the control group （P〈0.05）. Compared with before treat- ment, the plasma levels of T-Aoc in the observation group significantly increased, and the MDA decreased （P〈0.01）; In the control group, the plasma T-Aoc level slightly increased, and the MDA level slightly decreased, but the difference was not statistically significant （P〉0. 05）. Compared with control group, the improvement degree of oxidative stress indexes in the observation group were significantly better （P〈0.01）. The adverse reaction rate of the observation group was 10,4%, which was higher than 7.5% in the control group, while there was no statistically significant difference （P〉0.05）. Conclusion： VE and LEV could effectively reduce the seizure frequency, improve the EEG background activity, balance oxidative/antioxidant system, and control recurrence in the treatment of i

关 键 词：维生素E 左乙拉西坦 癫痫 抗氧化 丙二醛 

分 类 号：R742.1[医药卫生—神经病学与精神病学]