子宫颈小细胞癌的临床病理特征和预后分析  

Clinical Pathological Features and Prognosis Analysis of Small Cell Carcinoma of Cervix

作　　者：张子雯[1] 

机构地区：[1]宜春学院医学院病理学教研室,江西宜春336000

出　　处：《中外医疗》2017年第12期44-46,共3页China & Foreign Medical Treatment

摘　　要：目的探讨子宫颈小细胞癌的临床病理特征和预后分析。方法回顾性分析2013年12月—2015年12月该院肿瘤科收治的18例子宫颈小细胞癌(SCCC)患者的临床资料,总结其年龄、症状、病情FIGO分期、肿瘤大小及预后,采用免疫组化SP法检测Syn、CK、Cg A、CD56、EMA、NSE、TTF-1、Ki-67、S100的表达。结果所有18例患者中,年龄27~71岁,平均年龄(40.2±5.3)岁;16例表现为宫颈接触性出血或不规则阴道流血,2例表现为月经不规则伴经期延长,妇科检查发现宫颈赘生物;ⅠB1期8例、ⅠB2期5例、ⅡA2期2例、ⅢB期2例、ⅣB期1例;组织学特征为瘤细胞呈圆形或短梭形,大小及形态较一致,呈不规则巢片状分布,细胞质少,核深染,核仁不明显,多见核分裂象;15例为单纯宫颈小细胞癌,2例合并中分化腺癌,1例合并宫颈高级别上皮内瘤变;免疫组化中,NSE 100.00%,CK 100.00%,EMA88.89%,Syn 94.44%,CD 56 72.22%,Cg A 77.78%,TTF-1 33.33%,S100 11.11%,Ki-67 70%~90%;肿瘤大小在1.5~6 cm,11例患者于2年内死亡。结论 SCCC为神经内分泌癌,是高度恶性肿瘤,预后极差,免疫组化对该病的诊断有一定指导意义。Objective To study the clinical pathological features and prognosis analysis of small cell carcinoma of cervix.Methods 18 cases of patients with SCCC admitted and treated in our hospital from December 2013 to December 2015 were selected and the age, symptom, disease FIGO staging, tumor size and prognosis were summarized and the expressions of Syn, CK, Cg A, CD56, EMA, NSE,TTF-1, Ki-67,S100 were tested by the s-p immunohistochemical method. Results Of the18 cases of patients, the age was between 27 to 71, and the average age was(40.2±5.3), and 16 cases were with cervix contact bleeding or irregular vaginal bleeding and 2 cases were with irregular menstruation with prolonged menstrual bleeding,and the gynecological examination showed that cervical neoplasms, 8 cases in the ⅠB1 stage, 5 cases in the ⅠB2 stage, 2cases in the ⅡA2 stage, 2 cases in the ⅢB stage and 1 case in the ⅣB stage, and the histological characteristics were oncocyte in round or ellipse shapes, and the size and shape are consistent, showing the irregular nest with few cytoplasm and unobvious nucleolus, 15 cases were with simple small cell carcinoma of cervix, 2 cases were with moderate differentiated adenocarcinoma and 1 case with high-grade intraepithelial neoplasia, in the immunohistochemistry,NSE 100.00%,CK 100.00%,EMA 88.89%,Syn 94.44%,CD 56 72.22%,Cg A 77.78%,TTF-1 33.33%,S100 11.11%,Ki-67 70%~90%, and the tumor size was 1.5~6 cm, and 11 cases died in two years. Conclusion SCCC is the neuroendocrine carcinoma and a severe malignant tumor with bad prognosis, and immunohistochemistry is of a certain guidance significance to the diagnosis of the disease.

关 键 词：子宫颈小细胞癌 临床病理特征 预后观察 

分 类 号：R737.33[医药卫生—肿瘤]