帕金森病非运动症状中趋化因子的作用及研究进展  

Research Progress in Chemokines in the Non Motor Symptoms of Parkinson＇ s Disease

作　　者：董坤[1] 牛平[1] 

机构地区：[1]沈阳军区总医院神经内科,中国沈阳110016

出　　处：《国际老年医学杂志》2017年第3期121-125,共5页International Journal of Geriatrics

基　　金：辽宁省科技攻关课题（2010225003）

摘　　要：帕金森病（Parkinson’s disease，PD）的非运动症状（non-motor symptoms，NMS）主要包括神经精神症状、认知功能损害、睡眠障碍、自主神经功能失调、感觉障碍等。NMS对于PD早期诊断至关重要，但NMS的病理生理及生化机制尚不完全清楚。趋化因子（Chemokines，CK）是一类趋化细胞定向移动的细胞因子，通过作用其受体在炎症反应过程中发挥作用。越来越多的研究发现CK与PD及NMS的发病机制密切相关。本文将对NMS的临床表现、发病机制、CK与PD，特别是与NMS相关性研究的最新进展进行综述，并通过探讨以CK及其受体为靶点，调节CK信号传导途径的相关机制，为NMS诊断治疗的研究提供思路。The non -motor symptoms （NMS） of Parkinson＇ s disease （PD） includes neural psychiatric symptoms, cognitive impairment, sleep disorders, autonomic nerve dysfunction and sensory disturbances. More and more evidences show that NMS plays an important role in the early stage of PD, but the pathophysiological and biochemical mechanisms of NMS are not fully understood. Chemokines are chemotactic cytokines that can direct cells trafficking, conducting their functions via chemokine receptors in the process of inflammation. An increasing number of studies have showed that CK is closely related to the pathogenesis of PD and NMS. The review is to describe the clinical manifestations and pathogenesis of the non motor symptoms and the research progress in the relationship between chemokines and the non - motor symptoms. This paper provides a possible ideas for diagnosis and treatment of NMS, by making CK and its receptor as targets and regulating the CK signal transduction pathway.

关 键 词：趋化因子 非运动症状 单核细胞趋化蛋白-1 巨噬细胞炎性蛋白-1Α 

分 类 号：R742.5[医药卫生—神经病学与精神病学]