酒精性肝病与非酒精性脂肪肝患者血清GP73水平差异及意义  

Difference and clinical significance of serum GP73 between alcoholic liver disease and non-alcohol fatty liver disease

作　　者：周爱国 候俊[2] 冯鑫[3] 黄玉波[3] 李伯安[2] 

机构地区：[1]山东枣庄市中区医院,枣庄277100 [2]解放军302医院,北京100039 [3]首都医科大学附属北京地坛医院,北京100015

出　　处：《中华实验和临床病毒学杂志》2017年第2期162-164,共3页Chinese Journal of Experimental and Clinical Virology

摘　　要：3.39±66.91 ng/ml）的血清GP73水平显著高于NAFLD患者（55.38±21.00 ng/ml）;NAFLD患者的血清GP73也显著高于健康对照人群（43.91±19.02 ng/ml）.以NAFLD人群为参照＂健康＂人群,以酒精性肝病为＂患者＂人群,则GP73临床诊断ALD的ROC分析曲线下面积为0.66（95%CI：0.52~0.80,P=0.02）.以75.65 ng/ml为诊断cut-off值,则GP73诊断ALD的特异性为85.0%,敏感性为50.0%.结论 ALD患者血清GP73水平较健康对照人群及NAFLD患者显著升高,检测血清GP73对ALD和NAFLD之间有一定的鉴别诊断意义.ctive The present study was designed to evaluate the clinical significance of serum GP73 in patients with alcohol liver disease.Methods Thirty｜two patients with alcoholic liver disease （ALD）, 40 patients with non-alcohol fatty liver disease（NFLAD）, and 40 apparently healthy individuals were included in this study.Results Compared with Those of healthy control population（43.91±19.02 ng/ml）, the serum GP73 levels in ALD patients（93.39±66.91 ng/ml） were significantly increased, and also markedly higher than those of NFLAD patients （55.38±21.00 ng/ml）.Taken the NFALD as ＂healthy controls＂ population, and ALD population as ＂patients＂, the GP73 may be used to differentiate the ALD from NFLAD.The area of ROC analysis was 0.66（95%CI：0.52~0.80,P=0.02）.We set 75.65 ng/ml as the cut-off value for ALD diagnosis, the sensitivity and specificity were 50.0% and 85.0% respectively.Conclusion Serum GP73 levels in ALD patients were significantly higher than those of NFALD patients.GP73 may be a new marker for differentiating ALD from NFALD.

关 键 词：酒精性肝病 非酒精性脂肪肝 高尔基体蛋白73 鉴别诊断 GOLGI protein 73 

分 类 号：R575.5[医药卫生—消化系统]