老年阿尔茨海默病患者的尿甲醛和血清炎症因子水平及其临床意义  

Urine formaldehyde and serum inflammatory factors levels in elderly patients with Alzheimer's disease and its clinical significance

作　　者：马丽[1] 武海燕[1] 张力[1] 曹萌[1] 张守字[1] 苏涛[2] 赫荣乔[2] 

机构地区：[1]北京老年医院精神心理一科,北京市100095 [2]中国科学院生物物理研究所,脑与认知国家重点实验室,北京市100101

出　　处：《广西医学》2017年第5期633-635,共3页Guangxi Medical Journal

摘　　要：目的探讨老年阿尔茨海默病(AD)患者的尿甲醛和血清炎症因子水平及其临床意义。方法选取82例老年AD患者为AD组,正常老年人74例为对照组。测定两组血清白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)含量及尿甲醛水平,并在AD患者中分析血清IL-6、TNF-α、尿甲醛水平的相关性。结果 AD组尿甲醛、血清IL-6及TNF-α高于对照组(P<0.05);AD患者IL-6、TNF-α水平呈正相关(P<0.05),但尿甲醛水平与IL-6、TNF-α水平无相关性(P>0.05)。结论 AD患者血清慢性炎症因子及尿甲醛水平均升高,其可能与AD的发生有关。Objective To explore the urine formaldehyde and serum inflammatory factors levels in elderly patients with Alzheimer＇s disease （AD） and its clinical significance. Methods Eighty-two elderly patients with AD and 74 normal elderly were selected as AD group and control group respectively. The levels of serum interleukin-6 （IL-6）, serum tumor necrosis factor-α （TNF-α） and urine formaldehyde were detected in both groups. The correlation among the levels of serum IL-6, serum TNF-α and urine formaldehyde was analyzed in the patients with AD. Results The levels of urine formaldehyde,serum IL-6 and TNF-α in the AD group were significantly higher than those in the control group （P 〈 0. 05）. In the patients with AD,the IL-6 level positively correlated with TNF-α level,but the level of urine formaldehyde had no correlation with IL-6 or TNF-α level（P 〉0.05）. Conclusion Elevation of serum levels of chronic inflammation factors and urine formaldehyde exists in AD patients,which is probably related to the occurrence of AD.

关 键 词：阿尔茨海默病 甲醛 尿 白细胞介素-6 肿瘤坏死因子-Α 老年 

分 类 号：R749.1[医药卫生—神经病学与精神病学]