基于超高效液相色谱-质谱的代谢组学在肝脏疾病生物标志物发现中的作用  

Research advances in the identification of clinical biomarkers for liver diseases using metabolomics based on ultra-performance liquid chromatography-mass spectrometry

作　　者：周玄[1] 赖泳[1,2] 

机构地区：[1]大理大学药学与化学学院药理学教研室,云南大理671000 [2]云南省昆虫生物医药研发重点实验室,云南大理671000

出　　处：《临床肝胆病杂志》2017年第5期979-984,共6页Journal of Clinical Hepatology

基　　金：国家自然科学基金资助项目(81241139;81360511)

摘　　要：目前已有的肝脏疾病早期诊断的标志物往往敏感度和特异度较差,因此找到可应用于临床肝脏疾病早期诊断的﹑灵敏度和特异度高的生物标志物十分重要。新兴的代谢组学技术已获得广泛应用,有助于实现这一目标。对近年来基于超高效液相色谱-质谱的代谢组学在肝脏疾病生物标志物发现中的研究作一总结,并强调了其在肝病临床诊断﹑治疗及预后中的重要意义。The biomarkers currently known for the early diagnosis of liver diseases often have poor sensitivities and speeifieities, and thus it is very important to find new biomarkers with high sensitivities and speeifieities for the early diagnosis of liver diseases. The emerging metabolomies technology has been widely used and may help to achieve this goal. This article reviews the research advanees in the role of metabolomies based on ultra - performance liquid chromatography - mass spectrometry in the identification of biomarkers for liver diseases and emphasizes its significance in the early diagnosis, treatment, and prognosis evaluation of liver diseases.

关 键 词：肝疾病 代谢组学 生物学标记 超高效液相色谱-质谱 综述 

分 类 号：R575[医药卫生—消化系统]