移植物抗肿瘤效应抗大肠癌的实验研究  

Study of Graft Versus Tumor Effect for Colorectal Cancer

作　　者：张晓川[1] 唐树尧[1] 李吉友[1] 陈志男[1] 侯利民[1] 叶振宇[2] 

机构地区：[1]哈尔滨医科大学第一临床医学院,150000 [2]苏州大学附属第二医院,215004

出　　处：《实用癌症杂志》2017年第6期875-878,共4页The Practical Journal of Cancer

基　　金：苏州市2015年度第九批产业技术创新专项(编号:SYS201552)

摘　　要：目的通过移植物抗肿瘤效应和相关的细胞因子共同作用,建立一套综合的大肠癌辅助治疗方案。方法对BALB/C小鼠的皮下注射CT26肿瘤细胞来建立结肠癌小鼠模型,将CT26肿瘤模型鼠随机分组治疗,记录它们的存活天数、肿瘤大小、肿瘤生长抑制率。结果免疫细胞移植联合环磷酰胺(CP)治疗组的存活天数为(34.9±2.75)天,未治疗组存活天数(15.4±2.50)天(P<0.01)。联合治疗组肿瘤抑制率为94.3%。单独的CP治疗组和免疫细胞移植组肿瘤抑制率分别为99.4%和74.4%。结论免疫细胞移植存在(GVT)效应,有益于肿瘤的治疗,是潜在的细胞免疫治疗实体瘤的新方法。Objective To build a comprehensive adjuvant therapy for colorectal cancer through graft versus tumor effect （GVT） and related cell factor. Methods Subcutaneous injection of CT26 tumor cells of BALB/C mice was conducted to estab- lish the mouse model of coloreetal cancer The mice model were randomized into different group and recorded survival times, tumor size and tumor growth inhibition rates. Results The group treated by DLI ± CP survived （34.9 ± 2.75 ） days and the untreated group survived （ 15.4± 2.50） days （ P 〈 0.01 ）. The tumor inhibitory rate was 94.3 % in DLI ± CP group and CP or DLI alone group were 69.4% and 74.4%. Conclusion GVT effect is helpful for the treatment of tumor, it is a new method for the treat- ment of solid tumor cells in the future.

关 键 词：移植物抗肿瘤效应(GVT) 大肠癌 同种异基因脾免疫细胞输注移植(DLI) 环磷酰胺(CP) 

分 类 号：R735.34[医药卫生—肿瘤]