轻度认知功能损害的中医体质调查研究  

Investigation of Mild Cognitive Impairment TCM Constitution

作　　者：俞璐[1] 夏明[1] 冯青根[1] 金喆[1] 

机构地区：[1]上海中医药大学附属普陀医院中医内科,上海200062

出　　处：《辽宁中医杂志》2017年第5期897-900,I0001,共5页Liaoning Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金资助项目(81503370);上海市第六人民医院医疗集团课题研究基金资助项目(14-LY-01);上海市卫计委青年医师培养资助计划项目

摘　　要：目的:探讨上海中医药大学附属普陀临床医学院门诊及住院病人轻度认知功能损害(MCI)的好发体质类型。方法:选择98例MCI患者为病例组,另选择98例认知功能正常人群作为正常对照组;收集调查对象的一般资料、临床表现和舌脉进行分析,根据王琦等制订的9种基本中医体质类型的分类及其诊断表述依据判断中医体质类型。结果:多因素回归分析显示:(1)一般资料中,MCI组和正常对照组年龄层分布具有显著性差异(P<0.001),且随年龄增长,MCI患病比例明显增高;就业情况对MCI患者具有明显影响(P<0.05);性别和文化因素对MCI发病的影响并不明显(P>0.05)。(2)中医体质方面,MCI患者的中医体质构成中,痰湿质占39%,其次为瘀血质、阴虚质和湿热质,分别占20%、15%和13%,其他体质如气郁质、特禀质、平和质、气虚质和阳虚质患者均较少,占MCI患者的13%;MCI组和正常对照组对比分析,9种中医体质类型均无统计学差异(P>0.05)。结论:痰湿质可能为MCI的好发体质,阴虚质、瘀血质及湿热质亦为MCI的易发因素,积极改善体质类型对防治MCI具有重要作用。Objective：To explore the mild cognitive impairment TCM constitution on MCI patients from Putuo Hospital, Shanghai University of Traditional Chinese Medicine （inpatient and outpatient）. Methods：A clinical investigation was conducted in 196 respondents. Of the 196 respondents,98 respondents were assessed in MCI patients, and 98 respondents were assessed in normal controls. General information, clinical manifestation, tongue and pulse of the respondents were selected to put into the study, and MCI patients＇ TCM constitutions werejndged based on Classification and Diagnostic Expression Basis on 9 Basic Types of TCM Constitution drawn up by WANG Qi. Results：The multivariate regression analysis revealed that age distribution had significant difference between the two groups （P 〈 0. 001 ）, and the prevalence ratio increase as they grow older. And employment status had significant relevance to MCI （ P 〈 0. 05 ） , while gender and literacy had no significant relevance to MCI （ P 〉 0. 05 ）. The analysis of component ratio on TCM constitution showed that 39% of MCI patients were Phlegm - damp constitution,20% of MCI patients were blood stasis constitution, 15% of MCI patients were Yin deficiency constitution, and 13% of MCI patients were dampheat constitution. The other TCM constitutions such as Qi and blood stasis constitution, special constitution, Qi deficiency constitution and Yang deficiency constitution were fewer in the MCI patients accounting for 13% of the total. Nine basic types of TCM consti- tutions had no significant relevance between the two groups （ P 〉 0. 05 ）. Conclusion ： Phlegm - damp constitutioner is probably easy to suffer from MCI, and Yin deficiency constitution, blood stasis constitution and damp - heat constitution are risk factors of MCI. Improving constitution type actively plays a crucial role in MCI prevention.

关 键 词：轻度认知功能损害 中医体质 防治 

分 类 号：R742[医药卫生—神经病学与精神病学]