甲状腺癌组织中NF-κBp65、NF-κBp50及HMGB1表达及意义  

Expressions and Clinical significances of NF-κB p65,NF-κB p50 and HMGB1 in Thyroid Carcinoma Tissues

作　　者：杜朝阳[1] 陈燕玲[1] 谌秋华[1] 

机构地区：[1]解放军171医院,江西九江332000

出　　处：《解放军医药杂志》2017年第5期30-34,共5页Medical & Pharmaceutical Journal of Chinese People’s Liberation Army

摘　　要：目的探讨甲状腺癌组织中核因子-κB(NF-κB)p65、NF-κB p50及高迁移率族蛋白B1(HMGB1)的表达水平及临床意义。方法选择解放军171医院2013年1月—2015年12月切取的甲状腺组织标本212例进行研究,其中甲状腺癌组织122例,甲状腺腺瘤组织30例,甲状腺肿组织30例,正常甲状腺组织30例,比较各组NF-κB p65、NF-κB p50及HMGB1表达,并分析其与甲状腺癌临床特征的关系,以及三者之间的相关性。结果甲状腺癌组、甲状腺腺瘤组和甲状腺肿组的HMGB1、NF-κB p50和NF-κB p65阳性率均高于正常甲状腺组(P<0.01),甲状腺癌组和甲状腺腺瘤组均高于甲状腺肿组(P<0.01),甲状腺癌组高于甲状腺腺瘤组(P<0.01)。肿瘤直径≥1.0 cm和有淋巴结转移的甲状腺癌组织中NF-κB p65、NF-κB p50及HMGB1表达阳性率高(P<0.01,P<0.05)。NF-κB p65、NF-κB p50及HMGB1三者间呈显著正相关(r=0.356、0.645和0.275,P<0.05)。结论甲状腺癌组织中NF-κB p65、NF-κB p50及HMGB1均呈高表达,并且与肿瘤直径和淋巴结转移有关。Objective To discuss expressions and clinical significances of nuclear factor-κB p65 （NF-κB p65） , NF-κB p50 and high mobility group protein B1 （HMGB1） in thyroid carcinoma tissues. Methods A total of 212 sampies of thyroid tissues cut during January 2013 and December 2015 were recruited in the study, in which there were 122 cases of thyroid carcinoma tissues, 30 cases of thyroid adenoma tissues, 30 cases of goiter tissues and 30 cases of normal thyroid tissues. Expressions of NF-κB p65, NF-κB p50 and HMGB1 were compared in four groups, and their relationships with clinical features of thyroid carcinoma were analyzed, and correlations among NF-κB p65, NF-κB p50 and HMGB1 were also analyzed. Results Positive rates of HMGB1, NF-κB p65 and NF-κB p50 in thyroid carcinoma, thyroid adenoma and goiter groups were significantly higher than those in normal thyroid group （P 〈0.01 ） ; the positive rates in thyroid carcinoma and thyroid adenoma groups were significantly higher than those in goiter group （P 〈0. 01 ） ; the positive rates in thyroid carcinoma group were significantly higher than those in thyroid adenoma group （P 〈 0. 01 ）. Positive rates of NF-κB p65, NF-κB p50 and HMGB1 expressions of thyroid carcinoma tissues with tumor diameter equal or larger than 1.0 cm and lymph node metastasis were higher（P 〈0. 01, P 〈0. 05）. NF-κB p65, NF-κB p50 and HMGB1 showed significantly positive correlations with each other（r = 0. 356, 0. 645 and 0. 275, P 〈 0.05）. Conclusion Expressions of NF-κB p65, NF-κB p50 and HMGB1 in thyroid carcinoma tissues are higher, and the expressions are related to tumor diameter and lymph node metastasis.

关 键 词：甲状腺肿瘤 核因子-ΚB P50 核因子-ΚB p65 高迁移率族蛋白质类 

分 类 号：R736.1[医药卫生—肿瘤]