经颅多普勒辅助脑梗死静脉溶栓的安全性及有效性  

The safety and efficacy of intravenous thrombolysis assisted by transcranial doppler on acute cerebral infarction

作　　者：张伟[1] 黄志勇[1] 颜津津[1] 廖品君 吴修信[1] 贺文麟 

机构地区：[1]广州医科大学附属惠州医院神经内科,广东广州516002

出　　处：《包头医学院学报》2017年第5期3-5,共3页Journal of Baotou Medical College

基　　金：惠州市科技计划项目(20150801)

摘　　要：目的:探索经颅多普勒(trans-cranial doppler,TCD)辅助静脉溶栓的安全性及有效性。方法:49例患者随机分为对照组和TCD组,其中对照组患者25例,TCD组患者24例,对照组患者仅行静脉溶栓治疗,TCD组患者使用TCD超声头架固定超声监护探头,频率2 MHz,功率750 m W,在注射重组组织型纤溶酶原激活物过程中和注射后持续2 h监测,观察两组患者溶栓后的恢复效果。结果:两组患者的溶栓时间、美国国立卫生研究院卒中量表(national institute of health stroke scale,NIHSS)评分为影响患者溶栓死亡率的因素(P<0.05),TCD辅助溶栓死亡率及90 d后恢复情况差异无统计学意义(P>0.05)。结论:TCD辅助溶栓具有安全性,但其有效性尚待证实。Objective： To explore the safety and efficacy of intravenous thrombolytic therapy assisted by transcranial doppler（ TCD）. Methods： 49 patients were randomly divided into the control group and the TCD group,25 cases in the control group and 24 case in TCD group. The control group was treated only by intravenous thrombolytic therapy while the TCD group was monitored by a TCD ultrasound monitoring probe fixed on an ultrasonic head stand for 2 hours（ frequency 2MHz,power750 m W） during and after being injected by recombinant tissue plasminogen activator（ IV rt-PA）,with the recovery observed. Results： The thrombolytic time and the score of the national institute of health stroke scale（ NIHSS） were the factors influencing the death of patients after thrombolytic therapy（ P〈0. 05）. There was no difference as to the mortality and the recovery 90 days after the treatment（ P〉0. 05）. Conclusion： Thrombolytic therapy assisted by TCD is safe but more data are needed to prove its effectiveness.

关 键 词：急性脑梗死 经颅多普勒 溶栓治疗 重组组织型纤溶酶原激活物 

分 类 号：R743.3[医药卫生—神经病学与精神病学]