胰高血糖素对糖调节异常患者转归为糖尿病的影响  

Effect of glucagon on outcomes of patients with impaired glucose regulation to diabetes mellitus

作　　者：张仲慧[1] 张俊凤[2] 金成[3] 张景义[4] 

机构地区：[1]华北理工大学附属开滦总医院核医学科,河北唐山063000 [2]华北理工大学附属开滦总医院门诊部,河北唐山063000 [3]华北理工大学附属开滦总医院心内科,河北唐山063000 [4]华北理工大学附属开滦总医院内分泌科,河北唐山063000

出　　处：《华北理工大学学报（医学版）》2017年第3期195-199,共5页Journal of North China University of Science and Technology：Health Sciences Edition

摘　　要：(1)目的探讨胰高血糖素(Glucagon,Gg)对糖调节异常患者转归为糖尿病的影响。(2)方法对68例糖调节异常患者随访4年,根据随访结果将患者分为糖尿病组与非糖尿病组,对两组间的基线资料进行对比分析。(3)结果糖尿病组Ins30、Ins120均值低于非糖尿病组,组间差异有统计学意义,糖尿病组的Gg30、Gg60、Gg120值高于非糖尿病组,组间差异有统计学意义,表明早期胰岛素分泌减少和胰高血糖素升高在糖调节异常进展为糖尿病的过程中起作用。糖调节异常患者Gg60增高自然转归为糖尿病的风险增高。(4)结论糖调节异常患者口服葡萄糖后1h胰高血糖素值增高可作为进展为糖尿病的预测指标。Objective To explore the effect of Glucagon on the outcomes of patients with Impaired Glucose Regulation to diabetes mellitus.Methods 68 patients with IGR were followed up for 4 years,and were divided into diabetic group and non-diabetic group according the follow-up results, the baseline data were compared between the two groups.Results The value of Ins30,Ins120 in diabetes group were lower than in non-diabetic group, with statistically significant difference between groups, and the value of Gg30, Gg60, Ggl20 in diabetes group were higher than that in non-diabetic group, with significant difference between the two groups, suggesting that reduced early insulin secretion and increased glucagon played important roles in progression of IGR to diabetes.It was more likely to progress to diabete in patients with IGR who had a higher Gg60.Conclusion The inereased value of Gg60 in patients with IGR can be used a predictor of progression to diabete.

关 键 词：胰高血糖素 糖调节异常 转归 糖尿病 

分 类 号：R57[医药卫生—消化系统]