武汉地区宫颈感染人乳头瘤病毒患者年龄分布及感染类型特征  

Age distribution and infection types of human papillomavirus cervical infection in patients in Wuhan region

作　　者：肖晗[1] 孙红[1] 向飞艳[1] 夏倩[1] 刘秀珍[1] 向贇[1] 

机构地区：[1]华中科技大学同济医学院附属武汉儿童医院武汉市妇幼保健院,湖北武汉430016

出　　处：《中国感染控制杂志》2017年第5期399-403,共5页Chinese Journal of Infection Control

基　　金：国家自然科学基金资助项目(81201604);病毒学国家重点实验室开放基金项目(2015KF010);湖北省自然科学基金资助项目(2012FFB05301);武汉市卫生计生委临床医学科研项目(WX13B18)

摘　　要：目的了解武汉地区宫颈感染人乳头瘤病毒(HPV)患者年龄分布、HPV感染亚型,为HPV感染及宫颈癌的预防和治疗提供科学依据。方法对2015年1月—2016年3月武汉市妇女儿童医疗保健中心妇产科送检的9 915份宫颈刷取物标本进行HPV基因分型检测(21种亚型),对1 732例HPV阳性病例的临床数据进行统计分析。结果≤25、26~、36~、46~和≥56岁年龄组HPV阳性率分别为22.15%、15.90%、17.04%、19.97%和17.57%,各组差异具有统计学意义(χ~2=36.587,P<0.01),≤25和46~岁年龄组的阳性率均高于其他各组。不同年龄组患者单一感染和多重感染率比较,差异均有统计学意义(χ~2值分别为14.39、36.51,均P<0.05),单一感染以46~和≤25组最高,分别为15.41%、15.24%;多重感染以≤25和≥56年龄组最高,感染率分别为6.90%和5.86%。单一感染和多重感染所占比率分别为75.58%、24.42%,单一感染以HPV高危亚型为主(84.34%),多重感染以高危-高危复合型和高危-低危复合型为主,分别占60.52%、38.77%。以单一感染为主导的有HPV高危亚型33、68、31、16型和HPV低危亚型11型,其所致单一感染/多重感染的比值分别为3.13、2.03、1.71、1.67和2.00。结论武汉地区宫颈HPV感染率以≤25和46~岁年龄组较高,单一感染和多重感染HPV各亚型分布具有差异。ObjectiveTo investigate the age distribution and types of human papillomavirus （HPV） cervical infection in patients in Wuhan region, so as to provide scientific basis for the prevention and treatment of HPV infection and cervical cancer. Methods9 915 exfoliated cervical cell specimens from patients in Wuhan Medical and Health Center for Women and Children between January 2015 and March 2016 were performed HPV genotyping （21 subtypes）, clinical data of 1 732 HPV positive cases were statistically analyzed. ResultsHPVpositive rates in ≤25, 26～, 36～, 46～, and ≥56 age groups were 22.15%, 15.90%, 17.04%, 19.97%, and 17.57%,respectively （χ^2=36.587,P〈0.01）,HPVpositive rates in ≤25 and 46～ age groups were both higher than other age groups. There were significant differences in single infection and multiple infection rates among different age groups respectively（χ2=14.39, 36.51,respectively, both P〈0.05）,single infection rate was highest in 46～ and ≤25 age groups （15.41% and 15.24% respectively）;multiple infection rates was highest in ≤25 and ≥56 age groups （6.90% and 5.86% respectively）. The percentage of single infection and multiple infection were 75.58% and 24.42% respectively, the major single infection type was HPV highrisk subtype （84.34%）,the major multiple infection types were highrisk and highrisk compound subtype as well as highrisk and lowrisk compound subtype, accounting for 60.52% and 38.77% respectively. The main single infection types were HPV highrisk subtypes 33, 68, 31 and 16, as well as and lowrisk subtype 11, the ratios of single infection to multiple infection were 3.13, 2.03, 1.71, 1.67 and 2.00 respectively. ConclusionCervical infection rates in women in Wuhan region is high in ≤25 and 46～ age groups, there are differences in the distribution of different HPV subtypes of single infection and multiple infection.

关 键 词：人乳头瘤病毒 宫颈癌 多重感染 导流杂交技术 

分 类 号：R737.33[医药卫生—肿瘤]