小肠细菌过度生长与重症急性胰腺炎并发症相关性探讨  

Relevance between small intestinal bacterial overgrowth and complications of severe acute pancreatitis

作　　者：朱鸿明[1] 张玫[1] 李邦一 赵丹丹[1] 郑龙章[1] 

机构地区：[1]首都医科大学宣武医院消化科,北京100053

出　　处：《中国医药》2017年第6期884-887,共4页China Medicine

基　　金：北京市教育委员会科技计划面上项目（KM201310025015）

摘　　要：目的探讨小肠细菌过度生长（SIBO）与重症急性胰腺炎（SAP）并发症的相关性。方法选取2014年1月至2016年6月在首都医科大学宣武医院住院的SAP患者92例，以及同期入院的轻症急性胰腺炎（MAP）患者91例。患者均于人院48h内行氢呼气试验，检测患者是否存在SIBO。记录所有患者的并发症，包括感染、局部并发症、器官功能衰竭、系统性炎性反应综合征（SIRS）等。结果SAP组SIBO阳性率为26．1％（24／92），MAP组SIBO阳性率为8．8％（8／91），组间差异有统计学意义（P〈0．05）。Logistic回归方法分析显示器官功能衰竭和SIRS与SIBO有明显相关性（相关系数=2．092、0．068，均P〈0．05）。结论SIBO与SAP患者发生器官功能衰竭及SIRS具有相关性。Objective To investigate the relevance between small intestinal bacterial overgrowth （SIBO） and complications of severe acute panereatitis（SAP）. Methods From January 2014 to June 2016, 92 patients with SAP and 91 patients with moderate acute pancreatitis（MAP） in Xuanwu Hospital, Capital Medical University had hydrogen breath test in 48 h after admission to determine SIBO. Complications including infection, local complications, organ failure and systemic inflammatory response syndrome （SIRS） were recorded. Results The positive rate of SIBO was 26. 1% （24/92） in SAP group and 8.8% （8/91） in MAP group, the difference was statistically significant between groups（ P 〈 0. 05 ）. Logistic regression analysis showed that organ failure and SIRS were correlated with SIBO （ correlated coefficient = 2. 092, 0. 068 ; P 〈 0. 05 ）. Conclusion SIBO is correlated with complications of organ failure and SIRS in patients with SAP.

关 键 词：胰腺炎 器官衰竭 全身炎症反应综合征 小肠细菌过度生长 

分 类 号：R576[医药卫生—消化系统]