疏肝解郁胶囊联合帕罗西汀治疗抑郁症的临床疗效  

Clinical Effect of Shugan-jieyu Capsules Combined with Paroxetine on Depression

作　　者：郭彩娥 张玉英[2] 李卫红 邢秀敏[2] 陈川[2] 乔泽国 

机构地区：[1]河北省邯郸市精神病医院,056001 [2]河北省邯郸市第一医院,056002 [3]邯山区妇幼保健院,河北省邯郸市056001

出　　处：《实用心脑肺血管病杂志》2017年第4期88-90,共3页Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease

基　　金：邯郸市科学技术研究与发展计划项目(1323108149)

摘　　要：目的观察疏肝解郁胶囊联合帕罗西汀治疗抑郁症的临床疗效。方法选取2016年邯郸市精神病医院收治的抑郁症患者70例,采用随机数字表法分为对照组与研究组,每组35例。在常规治疗基础上,对照组患者予以盐酸帕罗西汀片治疗,研究组患者予以疏肝解郁胶囊联合盐酸帕罗西汀片治疗;两组患者均连续治疗4周。比较两组患者临床疗效,治疗前及治疗2、4周汉密尔顿抑郁量表(HAMD)评分,治疗2、4周不良反应症状量表(TESS)评分。结果研究组患者临床疗效优于对照组(P<0.05)。治疗前两组患者HAMD评分比较,差异无统计学意义(P>0.05);治疗2、4周研究组患者HAMD评分低于对照组(P<0.05)。治疗2、4周研究组患者TESS评分低于对照组(P<0.05)。结论疏肝解郁胶囊联合帕罗西汀治疗抑郁症的临床效果较好,可有效缓解患者临床症状且不良反应较少。Objective To observe the clinical effect of shugan - jieyu capsules combined with paroxetine on depression. Methods A total of 70 patients with depression were selected in the Psychiatric Hospital of Handan in 2016, and they were divided into control group and study group according to random number, each of 35 cases. Based on conventional treatment, patients of control group received paroxetine hydrochloride tablets, while patients of study group received shugan -jieyu capsules combined with paroxetine hydrochloride tablets; both groups continuously treated for 4 weeks. Clinical effect, HAMD score before treatment, after 2 and 4 weeks of treatment, TESS score after 2 and 4 weeks of treatment were compared between the two groups. Results Clinical effect of study group was statistically significantly better than that of control group （ P 〈 0. 05 ）. No statistically significant differences of HAMD score was found between the two groups before treatment （P〉 0.05 ）, while HAMD of study group was statistically significantly lower than that of control group after 2 and 4 weeks of treatment, respectively （ P 〈 0. 05 ）. TESS score of study group was statistically significantly lower than that of control group after 2 and 4 weeks of treatment （P 〈 0. 05 ）. Conclusion Shugan -jieyu capsules combined with paroxetine on depression has certain clinical effect in treating depression, can effectively relive the clinical symptoms with less adverse reactions.

关 键 词：抑郁症 帕罗西汀 疏肝解郁药 治疗结果 

分 类 号：R749.41[医药卫生—神经病学与精神病学]