常压敞开式离子化-离子迁移谱法快速筛查化妆品中3种禁用卤代水杨酰苯胺  

Rapid screening of three halogenated salicylanilines in cosmetics using ambient ionization coupled with ion mobility spectrometry

作　　者：郭项雨[1] 马强[1] 孟宪双[1] 吕悦广 王传现[3] 白桦[1] 

机构地区：[1]中国检验检疫科学研究院,北京100176 [2]中国科学院大学化学与化学工程学院 [3]上海出入境检验检疫局

出　　处：《卫生研究》2017年第3期467-471,共5页Journal of Hygiene Research

基　　金：中华人民共和国工业与信息化部行业标准计划项目(No.2015-0129T-QB);上海市科委技术标准专项项目(No.14DZ0501001)

摘　　要：目的采用常压敞开式离子化技术结合离子迁移谱技术,建立化妆品中3种禁用卤代水杨酰苯胺的快速筛查方法。方法化妆品样品无需繁琐前处理过程,水剂、唇膏及散粉类化妆品样品直接滴加或涂抹在Grade 3MM型色谱纸上,采用纸喷雾方式进行筛查检测;膏霜及香波类化妆品样品经金属微电极蘸取,采用萃取纳升喷雾方式进行筛查检测。结果 3种禁用卤代水杨酰苯胺的检出限为50μg/kg,离子迁移谱的分析时间小于15 ms。对于疑似阳性样品,进一步采用高效液相色谱-串联质谱法进行确证分析。结论该方法简捷、快速、成本低廉,适用于化妆品现场快速筛查。Objective A rapid analytical method had been developed for the screening of three halogenated salicylanilines in cosmetics using ambition ionization coupled with ion mobility spectrometry. Methods Without time-consuming pretreatment, cosmetic samples of lotion, lipstick and powder were added or smudged onto a Grade 3MM chromatography paper for paper spray ionization, cosmetic samples of cream and shampoo were simply loaded with a metal wire probe for extraction nano-electrospray. Results The limits of detection （LODs） for the three halogenated salicylanilides were 50 μg/kg. The instrumental analysis time for a single ion mobility spectrometry run was less than 15 ms. The suspected positive samples were subjected to further verification by high-performance liquid chromatography coupled with tandem mass spectrometry. Conclusion The method is simple, rapid, and with low cost and is suitable for rapid, on-site screening of cosmetics.

关 键 词：纸喷雾 萃取纳升喷雾 离子迁移谱 化妆品 卤代水杨酰苯胺 

分 类 号：R168[医药卫生—公共卫生与预防医学]