吉西他滨联合奥沙利铂治疗复发宫颈癌疗效观察  

Clinical Study on Oxaliplatin Combined With Gemcitabine in the Treatment of Recurrent Cervical Cancer

作　　者：林娴[1] 李慧灵[1] 郭月新 

机构地区：[1]福建省肿瘤医院妇科,福建福州350014

出　　处：《中国卫生标准管理》2017年第10期84-86,共3页China Health Standard Management

摘　　要：目的观察吉西他滨联合奥沙利铂治疗局部复发宫颈癌疗效及副作用。方法回顾性分析2010年1月—2015年1月福建省肿瘤医院治疗后局部复发病例24例,给予化疗,吉西他滨1 000 mg/m2,每次静脉滴注0.5 h,每个周期的第1、8 d静脉滴注,奥沙利铂130 mg/m^2每次静脉滴注2 h以上,每个周期的第2 d静脉滴注,21 d为1个周期。结果 24例中,完全缓解1例、部分缓解8例、稳定9例、进展6例,总有效率37.5%,中位无进展生存时间为7.5个月。主要副作用为胃肠道反应、骨髓抑制及神经毒性。结论吉西他滨联合奥沙利铂治疗局部复发宫颈癌,疗效显著,不良反应可以耐受。Objective Clinical effect and side effects of oxaliplatin combined with gemcitabine in treatment of recurrent cervical cancer is to be studied. Methods A retrospective analysis of 24 patients with recurrent cervical cancer who were treated in our hospital from January 2010 to January 2015. All the patients were given oxaliplatin combined with gemcitabine treatment, gemcitabin （1 000 mg/m2） on 1 d and 8 d, and oxaliplatin （130 mg/m2） on 2 d, three weeks as a therapeutic cyclic. Results Among 24 patients, 1 cases of CR, 8 cases of PR, 9 cases of SD, 6 cases of PD, the overall response rate was 37.5%, median progression free survival was 7.5 months. The main toxicities were gastrointestinal reation, bone marrow depression, peripheral neuritis. Conclusion Oxaliplatin combined with gemcitabine treatment is quite effective for recurrent cervical cancer,and adverse reactions can be tolerated.

关 键 词：吉西他滨 奥沙利铂 复发宫颈癌 

分 类 号：R736.3[医药卫生—肿瘤]