脂肪细胞因子Chemerin表达水平对妊娠期高血压的影响  

Effect of the expression of Chemerin on the hypertensive disorder complicating pregnancy

作　　者：伍立群[1] 李波[1] 肖凤仪[1] 徐丹[1] 方恋[1] 李东方[1] 

机构地区：[1]湖北医药学院附属随州医院妇产科,湖北随州441300

出　　处：《检验医学与临床》2017年第10期1394-1396,共3页Laboratory Medicine and Clinic

摘　　要：目的探讨脂肪细胞因子Chemerin表达水平对妊娠期高血压(HDCP)的影响。方法选取2015年6月至2016年7月到该院进行产前检查并住院待产的50例HDCP孕妇作为研究对象,其中轻度子痫前期(PE)20例,重度PE 13例,HDCP 17例。随机选取同期血压正常的孕妇50例作为对照组。比较4组研究对象的脂肪细胞因子Chemerin、收缩压(SBP)、舒张压(DBP)、血小板(PLT)、空腹血糖(FPG)、三酰甘油(TG)、低密度脂蛋白(LDL)、高密度脂蛋白(HDL)、空腹胰岛素(FINS)及胰岛素抵抗指数(HOMA-IR)水平的差异。采用Pearson相关性分析对Chemerin影响因素进行分析。结果 4组研究对象的PLT、FPG、LDL、HDL、FINS、HOMA-IR差异无统计学意义(P>0.05);HDCP组及重度PE组SBP、DBP、TG及Chemerin水平均显著高于对照组,以重度PE组最高,差异均有统计学意义(P<0.05)。经过Pearson相关性分析,Chemerin水平与SBP、DBP呈正相关,是HDCP的影响因素。结论 Chemerin水平高低可以作为识别HDCP的高危影响因素。Objective To investigate the effect of the expression of Chemerin in the hypertensive disorder complicating pregnancy.Methods From June 2015 to July 2016,50 patients with HDCP who went to our hospital for prenatal examination and delivery were selected as the research objects,including 20 cases with mild preeclampsia（PE）,13 cases with severe PE and 17 cases with HDCP.And 50 pregnant women with normal blood pressure were randomly selected as control group.Chemerin,SBP,DBP,PLT,FPG,TG,LDL,HDL,FINS and HOMA-IR levels were compared between the four groups.Pearson correlation analysis was used to analyze the influencing factors of Chemerin.Results PLT,FPG,LDL,HDL,FINS,HOMA-IR levels of four groups did not have statistical significance（P〉0.05）;SBP,DBP,HDCP,TG and Chemerin levels of HDCP group were significantly higher than that of the control group,among them the severe PE group was the highest,the differences were statistically significant（P〈0.05）.Pearson correlation analysis showed that Chemerin levels were positively correlated with DBP and SBP,which were the influencing factors of HDCP.Conclusion The level of Chemerin can be used as a high risk factor for the identification of HDCP.

关 键 词：脂肪细胞因子 CHEMERIN 妊娠期高血压 子痫前期 相关性分析 

分 类 号：R363[医药卫生—病理学]