唾液腺腺样囊性癌中多种异常高甲基化抑癌基因综述  

Aberrant methylation of tumor suppressor genes in salivary adenoid cystic carcinoma

作　　者：史悦怡 张蕾[1] 步荣发[1] 

机构地区：[1]解放军总医院口腔科,北京100853

出　　处：《解放军医学院学报》2017年第6期584-586,共3页Academic Journal of Chinese PLA Medical School

基　　金：国家自然科学基金项目(81071781)~~

摘　　要：腺样囊性癌(adenoid cystic carcinoma,ACC)是涎腺最常见的恶性肿瘤之一,现阶段研究显示在涎腺ACC中存在多个抑癌基因启动子区域的高甲基化,是ACC发病的遗传机制之一。抑癌基因的高甲基化在转录水平上使其发生低表达,影响细胞正常增殖分化,促进肿瘤发生。本文对近年来涎腺腺样囊性癌中的高甲基化抑癌基因研究进展作一综述,为腺样囊性癌的早期诊断及预后判断提供理论基础。Salivary adenoid cystic carcinoma （ACC） is one of the most common seen malignant salivary glands tumor. A large number of clinical studies have initially confirmed that ACC cells have hypermethylation in promoter regions of multiple tumor suppressor genes. Since ACC is generally insensitive to conventional chemotherapy and radiotherapy, using epigenetic agents, such as azacytidine, to modulate the activities of DNA methyltransferases and reverse the methylation status of tumor suppressor genes might be an attractive strategy for future adjuctive treatment of ACC, which could be combined with conventional therapies. We review recent research advances in tumor suppressor genes methylation in ACC, and provide a theoretical basis for the early diagnosis and prognostic prediction of ACC.

关 键 词：腺样囊性癌 抑癌基因 甲基化 涎腺肿瘤 

分 类 号：R739.87[医药卫生—肿瘤]