两个可调的四核铜Schiff碱配合物:自组装、晶体结构和抗癌活性  

Two Adjustable Tetranuclear Copper(Ⅱ) Schiff Base Complexes:Self-Assembly, Crystal Structures and Antitumor Activities

作　　者：陈延民[1] 姜岩[1] 洪思雨[1] 姚勇刚[1] 解庆范[1] 

机构地区：[1]泉州师范学院化工与材料学院,泉州362000

出　　处：《无机化学学报》2017年第6期1023-1029,共7页Chinese Journal of Inorganic Chemistry

基　　金：泉州师范学院学科建设资金;福建省大学生创新创业训练计划项目(No.201610399058)资助

摘　　要：通过水热反应制备了2个中心对称的四核铜Schiff碱配合物[Cu_4(H_2O)_2(μ-Brsth)2(μ_3-Brsth)_2](1)和[Cu_4(H_2O)_2(Brsth)_2(μ-Brsth)_2(μ2-4,4′-bipy)_2](2),其中H2Brsth为5-溴水杨醛缩噻吩-2-甲酰腙。2个配合物晶体属单斜晶系,空间群分别为P21/c和C2/c。2个配合物中所有的铜原子都是五配位,但每个配合物中4个Cu(Ⅱ)都处于2种类型的四方锥配位环境。在配合物1中4个铜原子被4个Schiff碱配体的酚盐氧分别以μ3-O和μ-O方式桥联形成椅式{Cu_4O_4}单元,而在配合物2中2对铜原子分别被2个Schiff碱配体的酚盐氧μ-O和2个桥联的μ2-4,4′-联吡啶连接形成环状的四核结构。体外抗癌活性的研究结果表明,配合物1和2对人肝癌细胞HEPG2均有较强的增殖抑制作用。A tridentate Schiff base ligand （H2Brsth）, derived from the condensation of 5-bromosalicylaldehyde and 2-acetylthiophene, hydrothermally reacted with Cu（Ⅱ） acetate in mixed-solvent of ethanol and water to yield tetranuclear complexes [Cu4（H2O）2（μ-Brsth）2（μ3-Brsth）2] （1） and [Cu4（H2O）2（Brsth）2（μ-Brsth）2（μ2-4,4＇-bipy）2] （2）, which were characterized by elemental analyses, IR, electronic spectra, thermogravimetric analysis and single crystal X-ray diffraction. The X-ray diffraction analyses reveal that 1 crystallizes in the monoclinic space group P21/c with Z=2 while 2 in monoclinic space group C2/c with Z=4. In 1 and 2 each Cu（Ⅱ） atoms are five-coordinated with both distorted square pyramidal geometries. In 1 four Cu（Ⅱ） atoms are held together by four μ-O and/or μ3-O type phenoxo oxygen atoms from four individual Schiff base ligands to form a chair-shaped {Cu4O4} unit. In 2 two pairs of Cu（Ⅱ） atoms join two μ2-4,4＇-bipy molecules and two μ-phenoxo oxygen atoms from two Schiff base, respectively, to form a cyclic tetranuclear structure. The in vitro antitumor activities of ligand and complexes were tested by MTT method, which results show that the complexes have strong in vitro antitumor activity against HEPG2 cancer cells lines.

关 键 词：铜配合物 SCHIFF碱 晶体结构 抗癌活性 

分 类 号：O614.121[理学—无机化学]