神经浸润与胃癌预后关系的Meta分析  

Meta-analysis of the relationship between perineural invasion and prognosis of gastric cancer

作　　者：陈路川[1] 魏晟宏[1] 叶再生[1] 林振孟 陈小玲[1] 王益[1] 卓长华[1] 李阳明[1] 

机构地区：[1]福建医科大学附属肿瘤医院胃肠肿瘤外科,福建福州350014

出　　处：《消化肿瘤杂志（电子版）》2017年第1期35-38,共4页Journal of Digestive Oncology(Electronic Version)

基　　金：福建省卫生计生委青年科研课题(2014-2-8)

摘　　要：目的神经浸润与胃癌预后之间的关系仍未达成一致,通过Meta分析,系统回顾分析神经浸润与胃癌预后的关系。方法通过中国知网、万方数据、Pub Med、Embase数据库中进行截止2016年的相关文献检索,合并HR及95%CI用于评估神经浸润对胃癌预后的价值。结果 14篇相关文献共17162例行胃癌根治术患者,神经浸润阳性率为23.1%。神经浸润与胃癌不良预后显著相关(HR=1.33,95%CI:1.08~1.57,P<0.05),亚组分析显示神经浸润与胃癌预后不受地区、神经浸润阳性率、论文质量得分影响。结论胃癌术后神经浸润阳性的患者预后差,神经浸润是影响胃癌预后的独立危险因素,也是术后辅助治疗的参考指标。Objective Currently, no consensus has been reached on the prognostic value of per- ineural invasion （PNI） in gastric cancer. The purpose of this meta-analysis was to systematically analyse the association between PNI and the prognosis of gastric cancer patients. Methods A systematic search of CN- KI,Wanfang datebase,PubMed,and Embase was performed for relevant reports published up to 2016. The pooled hazard ratio （HR） with 95% confidence intervals （CI） was used to estimate the prognostic effects. Resuits A total of forty studies incorporating 17162 patients who had undergone curative gastrectomy were in- cluded in the meta-analysis. The median rate of perineural invasion positive was 23.1%. Our results showed that PNI was significantly associated with poor prognosis （HR=1.33,95%, CI：1.08-1.57, P〈0.05）. Further subgroup analysis revealed that PNI and worse prognosis in gastric cancer patients is not affected by different regions,PNI positive rate and study quality. Conclusions Patient with PNI-positive gastric cancer has a poor overall survival. Perineural invasion is an independent prognostic factor and the decision to proceed with ad- juvant therapy after surgery.

关 键 词：胃癌 META分析 神经浸润 预后 

分 类 号：R735.2[医药卫生—肿瘤]