Dose-dependent neuroprotective effect of enoxaparin on cold-induced traumatic brain injury  

作　　者：Ilknur Keskin M.Yalcin Gunal Nilufer Ayturk Ulkan Kilic Mehmet Ozansoy Ertugrul Kilic 

机构地区：[1]Department of Histology and Embryology, Medipol University, Istanbul, Turkey [2]Department of Physiology, Medipol University, Istanbul, Turkey [3]Regenerative and Restorative Medical Research Center (REMER), Medipol University, Istanbul, Turkey [4]Department of Medical Biology, Medipol University, Istanbul, Turkey

出　　处：《Neural Regeneration Research》2017年第5期761-764,共4页中国神经再生研究（英文版）

摘　　要：Recent evidence exists that enoxaparin can reduce brain injury because of its anticoagulant activity. To investigate the potential therapeutic effect of enoxaparin on cold-induced traumatic brain injury, at 20 minutes after modeling, male BALB/c mouse models of cold-induced traumatic brain injury were intraperitoneally administered 3 and 10 mg/kg enoxaparin or isotonic saline solution. Twenty-four hours later, enoxaparin at 10 mg/kg greatly reduced infarct volume, decreased cell apoptosis in the cortex and obviously increased serum level of total antioxidant status. By contrast, administration of enoxaparin at 3 mg/kg did not lead to these changes. These findings suggest that enoxaparin exhibits neuroprotective effect on cold-induced traumatic brain injury in a dose-dependent manner.Recent evidence exists that enoxaparin can reduce brain injury because of its anticoagulant activity. To investigate the potential therapeutic effect of enoxaparin on cold-induced traumatic brain injury, at 20 minutes after modeling, male BALB/c mouse models of cold-induced traumatic brain injury were intraperitoneally administered 3 and 10 mg/kg enoxaparin or isotonic saline solution. Twenty-four hours later, enoxaparin at 10 mg/kg greatly reduced infarct volume, decreased cell apoptosis in the cortex and obviously increased serum level of total antioxidant status. By contrast, administration of enoxaparin at 3 mg/kg did not lead to these changes. These findings suggest that enoxaparin exhibits neuroprotective effect on cold-induced traumatic brain injury in a dose-dependent manner.

关 键 词：nerve regeneration NEUROPROTECTION traumatic brain injury cold-induced brain injury ENOXAPARIN anti-oxidative apoptosis neural regeneration 

分 类 号：R651.15[医药卫生—外科学]