非侵入性眼表综合分析仪观察可降解泪小点塞栓治疗中重度干眼的临床效果  

Application of Noninvasive Ocular Surface Analyzer in Monitoring Biodegradable Punctal Plug in the Treatment of Serious Dry Eye

作　　者：伍志琴[1] 杨燕宁[2] 袁静[2] 聂尚武[1] 王晓琴[1] 

机构地区：[1]湖北省荆州市中心医院眼科,湖北荆州434020 [2]武汉大学人民医院眼科中心,湖北武汉430060

出　　处：《武汉大学学报（医学版）》2017年第4期637-640,共4页Medical Journal of Wuhan University

摘　　要：目的:探讨VisiPlug可降解泪小管塞栓植入治疗中重度干眼的临床疗效以及非侵入性眼表综合分析仪Keratograph 5M在观察其治疗效果中的应用价值。方法:选择2015年7月至2015年8月于我院就诊的28例56眼确诊为中重度干眼的患者,使用VisiPlug可降解泪小管塞栓植入治疗,治疗前1d及治疗后2周、3个月、6个月用Keratograph 5M观察患者的眼表情况并进行统计学分析。结果:治疗后6个月时,22例(78.57%)患者症状明显缓解或消失,治疗前1d、治疗后2周、3个月、6个月时患者结膜充血评分平均值分别为(2.16±0.45)、(1.82±0.36)、(1.06±0.52)、(0.74±0.28),泪膜首次破裂时间平均值分别为(3.048±0.704)、(5.821±1.344)、(6.862±1.116)及(6.795±1.277)s,泪河高度平均分值分别为(0.174±0.075)、(0.256±0.073)、(0.362±0.065)、(0.402±0.026)mm,3种评价指标治疗前后差异均有统计学意义(F=96.458,138.172,109.365;P均<0.05)。最常见的并发症为局部异物感和泪溢。结论:VisiPlug可降解泪小管塞栓植入是临床上治疗中重度干眼的一种安全有效的方法,非侵入性眼表综合分析仪Keratograph 5M可以全面、客观地评价其临床疗效。Objective： To observe the availability and efficacy of VisiPlug biodegradable punctal plug in the treatment of serious dry eye and to evaluate the clinical value of noninvasive ocular surface analyzer Keratograph 5M in the follow-up. Methods： A total of 28 patients （56 eyes） were diagnosed as serious dry eye and treated with VisiPlug biodegradable punctal plug from July to August 2015. Keratograph 5M analyzer was used to observe the ocular surface condition at one day preoperatively and 2 weeks, 3 months, 6 months postoperatively. Results： The dry eye symptoms improved or disappeared in 22 （78.57%） patients 6 months postoperative. At baseline, 2 weeks and 3 months, 6 months after plug insertion, the mean score of conjunetiva hyperemia grading was （2.16±0.45）, （1.82±0.36）, （1.06±0.52）, and （0.74±0.28）, respectively, mean NIT-BUTf was （3. 048±0. 704） s, （5. 821±1. 344）s, （6. 862±1. 116）s, and （6. 795±1. 277） s, respectively, mean tear meniscus heihgt was （0. 174±0. 075） mm, （0. 256±0. 073） mm, （0. 362± 0. 065） ram, and （0. 402±0. 026） ram, respectively. All of these differences were statistically significant （F=96. 458, 138. 172, 109. 365, all P〈0.05）. Foreign body sensation and epiphora were the complications encountered in our study. Conclusion： The VisiPlug biodegradable punctal plug implantation is a safe and effective method for the treatment of severe dry eye. Keratograph 5M analyzer can evaluate the clinical effect comprehensively and objectively in the follow-up.

关 键 词：可降解泪小点塞栓 干眼 非侵入性眼表综合分析仪 

分 类 号：R777.34[医药卫生—眼科]