EBNA1/IgA血清学状态及动态变化相关的鼻咽癌发病风险研究  

Association between Serological Status and Fluctuation Modes of EBNA1/IgA and Risk of Nasopharyngeal Cancer

作　　者：盛炜[1] 吴标华[2] 吴文翰[1] 黄守杰[1] 吴婷[1] 郑亚[1] 夏宁邵[1] 季明芳[2] 

机构地区：[1]国家传染病诊断试剂与疫苗工程技术研究中心厦门大学公共卫生学院,厦门361002 [2]中山大学附属中山医院中山市肿瘤研究所,中山528403

出　　处：《病毒学报》2017年第3期338-344,共7页Chinese Journal of Virology

基　　金：国家科技支撑计划(项目号:2006BAI02A11);题目:鼻咽癌筛查及早诊早治方案的评价;中央补助地方卫生专项农村癌症早诊早治项目~~

摘　　要：分析EB病毒核抗原1-IgA抗体(EBNA1-IgA)的不同状态及变化趋势,并探讨人群的鼻咽癌发病风险。检测中山市小榄镇2009~2010年入组的16 695位30~59岁参加鼻咽癌筛查人群血清,按首次筛查和随访中EBNA1/IgA抗体状态将筛查人群进行分组,对照组为未参加筛查的两个镇区同年龄组人群,利用中山市肿瘤登记系统、死因登记系统随访至2014年12月31日,分析各组人群的鼻咽癌发病风险。与对照组相比,基线抗体阴性人群的发病风险比为0.46(95%CI 0.25~0.86),基线抗体阳性人群的发病风险比为31.1(95%CI 21.0~46.1);复查人群中上升组、持续阳性组的发病风险比分别为82.4(95%CI 36.1~188.2),26.4(95%CI 12.3~52.5),而下降组和波动组中未见病例。EBNA1/IgA基线阳性人群在5年中有很高的发病风险,复查人群中上升组和持续阳性组也有很高的发病风险,下降组和波动组发病风险较低。We wished to analyze the risk of nasopharyngeal cancer （NPC） in a population with different status and fluctuation modes of Epstein-Barr nuclear antigen 1 （EBNA1）/immunoglobulin A （IgA） antibody. Serology detection was conducted in 16,695 participants screened for NPC （30-59 years） enrolled from 2009 to 2010 in Xiaolan Town, Zhonghan City, China. Participants were divided into groups according to EBNA1/IgA antibody status at baseline and follow-up. Subjects who did not undergo screening in two neighboring towns of Xiaolan were designated the control group. All study participants were followed up to 31 December 2014 with linkage to a cancer registry. A population registry in Zhongshan City was used to analyze NPC risk in different groups. Compared with the control group, the relative risk （RR） of NPC in participants who were sero-negative and sero-positive at baseline was 0.46 （95% CI 0.25-0.86）and 31. 1 （21.0-46.1）, respectively. The RR of NPC in participants of the ascending group and persist-positive group who underwent retesting was 82.4 （95% CI 36.1-188.2） and 26.4 （12.3-52.5）, respectively. No NPC cases were observed in the descending group or fluctuating group. Individuals in the ascending group, persist-positive group and those who were EBNA1/IgA antibody-positive at baseline had a higher risk of NPC. A lower risk of NPC in the descending group and fluctuating group was observed compared with that in the control group.

关 键 词：鼻咽癌 EB病毒 EBNA1/IgA 筛查 发病率 

分 类 号：R73[医药卫生—肿瘤] R18[医药卫生—临床医学]