X线修复交叉互补基因3 Thr241Met(rs861539)基因多态性与淋巴瘤易感性Meta分析  

XRCC3 Thr241Met rs861539 polymorphism and lymphoma risk:a Meta-analysis

作　　者：柴婷婷[1] 田丽红[2] 黄劲龙[1] 沈建箴[1] 

机构地区：[1]福建省血液病研究所、福建省血液病学重点实验室、福建医科大学附属协和医院,福州350001 [2]福建省厦门市第二医院风湿血液科

出　　处：《临床血液学杂志》2017年第3期372-376,共5页Journal of Clinical Hematology

基　　金：国家和福建省重点专科建设项目资助(No:2010301#)

摘　　要：目的:通过Meta分析方法探讨X线修复交叉互补基因3 XRCC3 Thr241Met(rs861539)多态性与淋巴瘤易感性的关系。方法:通过检索2016年4月之前PubMed,Embase,Cochrane Library,Web of Science and the Chinese Biomedical Literature Database的相关文献,我们进行了一项荟萃分析以研究它们之间的关系。结果:在这项荟萃分析中,最后我们纳入了854例病例组和1 081例对照组。结果显示XRCC3的5种基因模型与淋巴瘤的风险之间无统计学意义(TT vs.CC,OR=1.05,95%CI=0.79~1.38,P=0.75;TT+CT vs.CC,OR=1.01,95%CI=0.84~1.22,P=0.88;TT vs.CT+CC,OR=1.02,95%CI=0.80~1.32,P=0.86;T vs.C,OR=1.01,95%CI=0.89~1.16,P=0.84;CT vs.CC,OR=1.08,95%CI=0.79~1.48,P=0.62)。结论:Meta分析结果表明:尚没有足够的证据证明XRCC3 Thr241Met(rs861539)多态性与淋巴瘤的风险之间有联系。Objective：To explore the relationship between X-ray repair cross-complementing group 3 （XRCC3） Thr241Met （rs861539） polymorphism and lymphoma risk by Meta-analysis. Method.. We identified studies by searching PubMed, Embase, Cochrane Library, Web of Science and the Chinese Biomedical Literature Database （CBM） until April 2016. Odds ratio （OR） and 95% confidence interval （CI） were used to evaluate the association. Result：Finally 854 cases and 1081 controls were included in this Meta-analysis. There was not statisti- cally significant association between XRCC3 and lymphoma risk in the 5 models （TT vs. CC,OR = 1.05,95% CI= 0.79 to 1.38,P=0.75;TT＋CT vs. CC,OR=1.01,95%CI=0.84 to 1.22,P=0.88;TT vs. CT＋CC,OR= 1. 02,95;CI=0. 80 to 1.32,P=0.86;T vs.C,OR=1.01,95%CI=0.89 to 1.16,P=0.84;CT vs. CC,OR= 1.08,95% CI = 0.79 to 1.48, P=0.62）. Conclusion： There is no evidence suggesting the relationship between XRCC3 Thr241Met （rs861539） polymorphism and lymphoma risk.

关 键 词：XRCC3基因 基因多态性 淋巴瘤 

分 类 号：R733.3[医药卫生—肿瘤]