肝脏巨噬细胞及其在肝损伤中的作用  

Liver macrophages: Role in liver injury

作　　者：李静[1] 季菊玲[1] 

机构地区：[1]南通大学医学院病理系,江苏省南通市226001

出　　处：《世界华人消化杂志》2017年第14期1223-1230,共8页World Chinese Journal of Digestology

基　　金：国家自然科学基金资助项目;Nos.81572871;81761128018;江苏省自然科学基金资助项目;No.BK20151277~~

摘　　要：肝脏巨噬细胞来源和功能复杂,包括肝脏固有巨噬细胞和单核细胞来源的浸润巨噬细胞,在宿主防御机制及维持机体内环境稳定中起着重要作用,也是参与肝脏损伤和修复的主要细胞成分.解析不同来源肝脏巨噬细胞在不同病因导致肝损伤过程中表型分化、生物学作用的动态变化及其分子机制,对理解肝损伤的病理过程,探索以肝脏巨噬细胞为靶点预防和治疗肝损伤以及肝纤维化的方案具有重要意义.The origin and function of hepatic macrophages are complicated. Hepatic macrophages consist of resident and infiltrating monocyte-derived macrophages. They play important roles in host defense and in maintaining homeostasis, and are main cell components that are involved in liver injury and restoration. It is important to trace the dynamic changes in the phenotypes and biological functions of hepatic macrophages of different origins in the context of liver injury caused by distinct factors, and to explore the underlying mechanisms. Research in this field will help us to understand the pathological processes of liver injury, and to develop preventive and therapeutic strategies for liver injury and subsequent fibrosis by targeting liver macrophages.

关 键 词：固有巨噬细胞 浸润巨噬细胞 肝损伤 

分 类 号：R575[医药卫生—消化系统]