甲状腺乳头状癌超声造影特征与癌细胞增殖、侵袭的相关性  

Correlation of thyroid papillary carcinoma ultrasound contrast characteristics with cancer cell proliferation and invasion

作　　者：万静[1] 吕娟[1] 

机构地区：[1]新疆自治区人民医院超声科,新疆乌鲁木齐830001

出　　处：《海南医学院学报》2017年第8期1134-1137,共4页Journal of Hainan Medical University

基　　金：新疆维吾尔自治区科研项目(20140317)~~

摘　　要：目的:探讨甲状腺乳头状癌超声造影特征与癌细胞增殖、侵袭的相关性。方法:收集在本院进行手术治疗的甲状腺乳头状癌患者128例,经超声造影明确肿瘤组织、周围正常组织的峰值强度(PI)、曲线下面积(AUC),进一步根据PI、AUC中位数将其分为高PI组、低PI组,高AUC组、低AUC组各64例。采用荧光定量PCR法测定肿瘤组织中增殖、侵袭基因mRNA表达量。结果:肿瘤组织中PI、AUC水平均低于周围正常组织(P<0.05);低PI组增殖基因EZH2、Livin、hTERT、HMGA1、Wip1 mRNA表达量均高于高PI组,侵袭基因Ki-67mRNA表达量高于高PI组,P53、MRP-1mRNA表达量低于高PI组(P<0.05);低AUC组增殖基因EZH2、Livin、hTERT、HMGA1、Wip1 mRNA表达量均高于高AUC组,侵袭基因Ki-67 mRNA表达量高于高AUC组,P53、MRP-1 mRNA表达量低于高AUC组(P<0.05)。结论:甲状腺乳头状癌超声造影参数PI、AUC水平可量化反映癌细胞增殖、侵袭活性。Objective： To study the correlation of thyroid papillary carcinoma ultrasound contrast characteristics with cancer cell proliferation and invasion. Methods.. A total of 128 patients with thyroid papillary carcinoma who received surgical treatment in the hospital between May 2013 and May 2016 were collected, ultrasound contrast was used to make clear the peak intensity （PI） and area under the curve （AUC） of tumor tissue and surrounding normal tissue, and the median of PI and AUC was referred to further divide the patients into high PI group and low PI group as well as high AUC group and low AUC group, 64 eases in each group. Fluoreseent quantitative PCR was used to determine proliferation and invasion gene mRNA expression in tumor tissues. Results： PI and AUC levels in tumor tissue were significantly lower than those in surrounding normal tissue （P〈0.05）; proliferation genes EZH2, Livin, hTERT, HMGA1 and Wipl mRNA expression of low PI group were significantly higher than those of high PI group, and invasion gene Ki-67 mRNA expression was significantly higher than that of high PI group while P53 and MRP-1 mRNA expression were significantly lower than those of high PI group （P〈0.05） ; proliferation genes EZH2, Livin, hTERT, HMGA1 and Wipl mRNA expression of low AUC group were significantly higher than those of high AUC group, and invasion gene Ki-67 mRNA expression was significantly higher than that of high AUC group while P53 and MRP-1 mRNA expression were significantly lower than those of high AUC group （P〈0.05）. Conclusions： Thyroid papillary carcinoma ultrasound contrast parameters PI and AUC levels can quantifiably reflect the cancer cell proliferation and invasion activity.

关 键 词：甲状腺乳头状癌 超声造影 增殖基因 侵袭基因 

分 类 号：R736.1[医药卫生—肿瘤]