复方樟柳碱颞浅动脉旁皮下注射联合丹红离子导入治疗眼睑痉挛合并干眼的临床疗效  

Clinical effect of subcutaneous injecting the compound anisodine besides the superficial temporal artery combined with danhong iontophoresis in treatment of blepharospasm with dry eye

作　　者：朱彦霞[1] 姜士军[1] 蒋燕玲[1] 李学民[2] 

机构地区：[1]江苏省连云港市第二人民医院眼科,222000 [2]北京大学第三医院眼科,100191

出　　处：《中华眼科医学杂志（电子版）》2017年第2期78-83,共6页Chinese Journal of Ophthalmologic Medicine(Electronic Edition)

基　　金：首都临床特色应用研究项目(Z141107002514042)

摘　　要：目的探讨复方樟柳碱颞浅动脉旁皮下注射联合丹红离子导入治疗眼睑痉挛合并干眼的临床疗效。方法收集2014年9月至2016年6月于连云港市第二人民医院眼科接受治疗的眼睑痉挛合并干眼的64例(75只眼)患者的临床资料。按照数字表法将患者随机分为对照组和治疗组。其中,对照组患者30例(34只眼),治疗组患者34例(41只眼)。对照组患者口服甲钴胺胶囊,并联合玻璃酸钠滴眼液滴眼。治疗组患者在对照组治疗方法的基础上,同时使用复方樟柳碱颞浅动脉旁皮下注射联合丹红离子导入法进行治疗。两组患者在治疗前和治疗3个月后,分别行眼睑痉挛强度分级评估和Schirmer泪液分泌试验(SIt)、泪膜破裂时间(BUT)及角膜荧光素染色等干眼检查。SIt、BUT及角膜荧光素染色的检查结果均采用均数±标准差(±s)表示,采用独立样本t检验进行组间比较,并采用配对样本t检验进行治疗前后的比较。将眼睑痉挛强度分为4个等级,并采用Kruskal-Wallis H秩和检验对两组患者治疗前的眼睑痉挛强度分级分布情况进行比较。眼睑痉挛的治疗效果采用例数和百分数(%)表示,并采用χ~2检验对总有效率进行比较。结果对照组患者治疗前的SIt、BUT及角膜荧光素染色的检查结果分别为(2.43±1.17)mm/5 min、(2.67±1.03)s及(5.10±1.71)分;治疗后分别为(10.00±2.99)mm/5 min、(9.10±2.44)s及(1.67±1.15)分。将对照组患者治疗前后的SIt、BUT及角膜荧光素染色的检查结果进行比较,差异有统计学意义(t=9.12,10.26,5.48;P<0.05)。治疗组患者治疗前SIt、BUT及角膜荧光素染色的检查结果分别为(2.15±1.02)mm/5 min、(2.59±0.86)s及(5.12±1.55)分;治疗后分别为(13.02±3.22)mm/5 min、(12.00±2.20)s及(1.09±0.90)分。将治疗组患者治疗前后的SIt、BUT及角膜荧光素染色的检查结果进行比较,差异有统计学意义(t=9.10,10.50,4.67;P<0.05)。将治疗组与对照组患者治疗前的SObjective To investigate the clinical effect of subcutaneous injecting the compound anisodine besides the superficial temporal artery combined with danhong iontophoresis in treatment of blepharospasm with dry eye.Methods The clinical data of 64 patients （75 eyes） with blepharospasm and dry eye treated in The Second People′s Hospital of Lianyungang were collected from September 2014 to June 2016.According to the digital table method, the patients were randomly divided into control group and treatment group.Among them, there were 30 cases （34 eyes） in the control group and 34 cases （41 eyes） in the treatment group.30 cases （34 eyes） enrolled in the control group were treated with oral mecobalamin capsule and sodium hyaluronate eye drops.On the basis of the control group′s treatments, 34 cases （41 eyes） enrolled in the treatment group were treated by injecting the compound anisodine besides the superficial temporal artery combined with Danhong iontophoresis.Before and after treatment,two groups of patients were examined in classification of blepharospasm, SchirmerⅠtest （SIt）, breakup time （BUT）, and corneal fluorescent staining, respectively.SIt wetted length, BUT, and corneal fluorescein staining scores were presented as mean ± standard deviation（±s）, and compared by independent samples t-test between two groups, and compared by paired samples t-test before and after treatment.The intensity of blepharospasm was divided into four grades, and the results were compared by Kruskal-Wallis H rank sum test.The therapeutic effect of blepharospasm was expressed as the number of cases and percentage （%）, and the total effective rate was compared by chi square test.Results Before the treatment, the results of SIt, BUT and corneal fluorescent staining in the control group were （2.43±1.17） mm/5 min, （2.67±1.03） s and （5.10±1.71） points;after treatment, they were （10.00±2.99） mm/5 min, （9.10±2.44） s and （1.67±1.15） points, respectively.The results of SIt,

关 键 词：眼睑痉挛 干眼 复方樟柳碱 离子导入 

分 类 号：R777[医药卫生—眼科]