脉冲电磁场加速高原应激性胃溃疡愈合的研究  

Study on the pulsed electromagnetic fields promoting cure of plateau stress ulcer

作　　者：焦明克[1] 冯景[1] 楼林[1] 张鹏[1] 耿西亮[1] 依米提.赛达孜木 史衍辉[1] 

机构地区：[1]新疆军区总医院医学工程科,乌鲁木齐830000

出　　处：《医疗卫生装备》2017年第5期36-38,共3页Chinese Medical Equipment Journal

基　　金：新疆维吾尔自治区自然科学基金项目(2015211C248)

摘　　要：目的 :明确15 Hz、30 mT低频脉冲电磁场(low frequency pulsed electromagnetic field,LFPEF)非热生物效应对高原应激性胃溃疡愈合过程中溃疡伤口变化情况的影响。方法:将30只SD雄性大鼠随机等分为3组:空白对照组、正常愈合组、照射治疗组。模拟高原低压缺氧习服结合无水乙醇灌胃刺激的方法构建大鼠高原应激性溃疡模型。采用LFPEF发生装置产生频率为15 Hz、占空比为40%、强度为30 m T的脉冲电磁场对照射治疗组大鼠胃部区域进行照射,3 h/d。照射治疗6 d后,通过溃疡大体观察、测定胃液p H值变化和胃黏膜损伤溃疡指数(ulcer index,UI)的方法对各组大鼠溃疡愈合情况进行评估。结果:溃疡大体观察结果表明造模6 d后,正常愈合组溃疡程度明显比照射治疗组严重;照射治疗组胃液p H测量值和UI测量值均明显异于正常愈合组,接近于空白对照组。结论:LFPEF的非热生物效应能够促进高原应激性溃疡的愈合。Objective To determine the effects of non-thermal biological effect of low frequency pulsed electromagnetic field （LFPEF） with 15 Hz and 30 mT on ulcer wound during the plateau stress ulcer cure. Methods Thirty male Sprague-Dawley rats were assigned to three equal groups： control, normal cure group （NC） and exposure treatment groups （ET）. The plateau rats stress ulcer models were constructed with the combination method of a hypoxic and low-pressure acclimation and the stimulation of absolute ethyl alcohol irrigating stomach. The LFPEF equipment generated the LFPEF of 15 Hz, 40% duty cycle and 30 mT to expose and treat the rats stomach of ET group with the frequency of 3 hours each day. After 6 days of exposure treatment, the stress ulcer cure situation of each group was evaluated by the methods of macroscopic observation, the gastric juice pH values detection and ulcer index （UI） measurement. Results After 6 days of model, the macroscopic observation showed that the ulcer of NC group was worse than the that of ET group （P〈0.05）. The pH values and UI of ET group were significantly different with those of NC group, and closed to those of the control group. Conclusion The nonthermal biological effect of LFPEF could promote the plateau stress ulcer cure. [Chinese Medical Equipment Journal, 2017,38（5） ：36-38]

关 键 词：脉冲电磁场 应激性溃疡 溃疡指数 愈合 

分 类 号：R573.1[医药卫生—消化系统]