SPECT-CT与MRI在鼻咽癌早期颅底侵犯方面的比较研究  

Comparative Study of SPECT-CT and MRI in Early Skull Base Invasion of Nasopharyngeal Carcinoma

作　　者：赵波沣[1] 陈树平[1] 吕涵青[1] 胡元明[1] 陈健湘[1] 

机构地区：[1]广东省深圳市中医院,广东深圳518033

出　　处：《中国医学创新》2017年第15期124-127,共4页Medical Innovation of China

基　　金：深圳市科创委计划项目(201103384)

摘　　要：目的:探讨比较SPECT-CT与MRI在鼻咽癌早期颅底侵犯方面的检测能力。方法:选取2014年10月-2015年9月本院经病理确诊的鼻咽癌(NPC)患者60例,经患者同意后,拟治疗前2周内行鼻咽部增强MRI和SPECT-CT检查。另选取20例无全身骨转移、无颅底骨侵犯的非NPC患者作为对照参考组(了解正常头颅SPECT-CT影像表现及计算L/O值的均数±2个标准差,以确定半定量分析标准的正常值范围),比较SPECT-CT与MRI在鼻咽癌早期颅底侵犯方面的检测能力。结果:60例鼻咽癌患者,经MRI检查颅底骨侵犯阳性患者55例,阳性检出率为91.7%(55/60);经SPECT-CT检查颅底骨侵犯阳性患者54例,阳性检出率为90.0%(54/60),经SPECT-CT同机融合检查出的阳性检出率与MRI检查的阳性检出率比较,差异无统计学意义(字2=2.34,P>0.05)。结论:SPECT-CT同机融合显像对鼻咽癌颅底侵犯检测与MRI无明显差异,而SPECT-CT同机融合显像是在全身骨显像基础上进行的局部检查,没有明显增加患者的经济负担,可以在临床推广应用。Objective： To discuss and compare the detection ability of SPECT/CT and MRI in skull base invasion of nasopharyngeal carcinoma.Method： 60 patients with nasopharyngeal carcinoma （ NPC ） diagnosed by pathology from October 2014 to September 2015 in our hospital were enrolled, after the consent of the patient who were detected by enhanced SPECT-CT and MRI before 2 weeks of treatment. The other 20 cases without bone metastasis, skull base invasion of non NPC patients were enrolled as control group （ reference understanding of normal brain SPECT-CT imaging and L/O value calculation mean ±2 standard deviation, to determine the normal range of semi quantitative analysis standard ）, the ability of SPECT-CT and MR1 in the detection of early skull base invasion in nasopharyngeal carcinoma was compared.Result： There were 55 cases of positive skull base bone invasion in the 60 cases of nasopharyngeal carcinoma examined by MRI, and the positive rate was 91.7% （ 55/60 ）, there were 54 eases of positive skull base bone invasion examined by SPECT-CT, of which the positive rate was 90.0% （ 54/60 ）, the positive rate of SPECT-CT fusion compared with the positive rate of MRI examination, there was no statistically significant difference （ χ^2=2.34, P〉0.05 ） .Conclusion： There is no significant difference between SPECT-CT fusion imaging in the detection of skull base invasion and MRI, the SPECT-CT fusion imaging is a local examination on the basis of whole body bone imaging, it can not increase the economic burden of patients, and can be widely used in clinical practice.

关 键 词：SPECT—CT MRI 鼻咽癌 早期颅底侵犯 

分 类 号：R739.63[医药卫生—肿瘤]