SSTR2、Livin和Survivin在结肠癌组织中的表达及其意义  

Expressions of SSTR2,Livin and survivin in colon carcinomas and their clinical significance

作　　者：王伟宁 徐赛群 刘丽 黄萍 潘佳 叶冠男 刘伟 

机构地区：[1]湖南省长沙市第一医院消化内科,湖南长沙410005

出　　处：《中国现代医学杂志》2017年第10期52-56,共5页China Journal of Modern Medicine

基　　金：长沙市科技局计划项目(No:K1403059-31)

摘　　要：目的探讨生长抑素受体2(SSTR2),凋亡抑制因子Livin和存活素(Survivin)在结肠正常黏膜、结肠腺瘤、癌旁组织及结肠癌组织中的表达水平的变化规律及临床意义。方法采用逆转录聚合酶链反应(RT-PCR)方法检测收集到的30例结肠正常黏膜、30例结肠腺瘤、30例结肠癌旁组织、30例结肠癌组织中SSTR2、Livin和Survivin mRNA的表达情况,对其表达水平进行测定,分析不同组织表达阳性率及表达强度的差别。结果结肠癌标本中Livin和Survivin mRNA阳性表达率与结肠腺瘤比较明显升高,差异有统计学意义(P<0.05)。而SSTR2mRNA的阳性表达率与结肠腺瘤比较明显降低,,差异有统计学意义(P<0.05)。Livin和Survivin mRNA表达水平在结肠正常黏膜、结肠腺瘤、结肠瘤旁组织、结肠癌组织为逐渐增高趋势,而SSTR2mRNA为逐渐下降趋势。结论 SSTR2、Livin和Survivin在结肠黏膜从腺瘤到癌的转变过程中起着重要作用。Objective To investigate the expressions of SSTR2, Livin and survivin in normal mucous membrane of colon, colon adenoma, colon carcinomas and their adjacent tissues and the clinical significance. Methods The qRT-PCR technique was utilized to detect the mRNA of SSTR2, Livin and stlrvivin in colonic adenomas of 30 cases, colonic carcinomas and their adjacent tissues of 30 cases, and normal colon mucous membrane of 30 cases. Results The rates of positive expressions of Livin mRNA and survivin mRNA in the colon carcinomas were significantly higher than those in the colon adenomas （P 〈 0.05）. The expression rate of SSTR2 mRNA in the colon carcinomas was significantly lower than that in the colon adenomas （P 〈 0.05）. The expressions of Livin and survivin mRNA in the normal colon mucous membrane, the colon adenomas, the adjacent tissue of carcinomas, and the colon carcinomas had a gradually increased tendency, while the expressions of SSTR2 mRNA had a gradually decreased tendency. Conclusions SSTR2, Livin and survivin play important roles in the transition of colon mucosa from adenoma to cancer.

关 键 词：SSTR2 LIVIN SURVIVIN 结肠腺瘤 结肠癌 

分 类 号：R735.3[医药卫生—肿瘤]