持续性躯体形式疼痛障碍病人事件相关电位时空模式研究  

A STUDY ON SPACE-TIME MODEL OF EVENT RELATED POTENTIAL OF PATIENTS WITH PERSISTENT SOMATOFORM PAIN DISORDER

作　　者：杨从敏[1] 程泓[2] 李柄佑 金荣疆[1] 郑重[3] 

机构地区：[1]成都中医药大学养生康复学院康复教研室,成都610075 [2]成都中医药大学第二临床医学院,成都610075 [3]四川大学华西医院/华西临床医学院,成都610041

出　　处：《中国疼痛医学杂志》2017年第5期345-352,共8页Chinese Journal of Pain Medicine

摘　　要：目的:观察持续性躯体形式疼痛障碍(persistent somatoform pain disorder,PSPD)病人事件相关电位晚期正成分(late positive potential of event related potential,ERP-LPP)的时空模式特征。方法:随机选取15例PSPD病人纳入实验组,15例正常受试者纳入对照组,评定两组ERP-LPP时空模式特征。结果:对照组ERP-LPP的正性图片波幅较高,空间效应可见颞枕叶皮层中度兴奋,稍向颞叶左部漂移,差异有统计学意义(P<0.05);中性图片时空模式特征不显现;负性图片波幅较高,空间效应可见额、顶、颞及枕叶中部及右部皮层中高度兴奋,差异有统计学意义(P<0.05)。实验组ERP-LPP的正性图片波幅降低,空间效应可见额、顶、颞及枕叶中部皮层中度兴奋,差异有统计学意义(P<0.05);中性图片时空模式特征不显现;负性图片波幅升高,空间效应可见额、顶、颞及枕叶的中部及左部皮层高度兴奋,差异有统计学意义(P<0.05)。结论:PSPD病人存在额叶调控情绪能力紊乱,可考虑将ERP-LPP运用于PSPD病人的情绪检测。Objective：To observe space-time pattern characteristics of late positive potential of event related potential of persistent somatoform pain disorder patients.Methods： 15 PSPD patients were randomly selected in experimental group and 15 normal subjects were included into control group. The space-time pattern characteristics of ERP-LPP of two groups were evaluated.Results： The amplitude of positive pictures in control group was relatively higher, the temporal and occipital lobe was moderate excitatory in spatial effect, and it lightly moved to left cortex of temporal lobe （P 〈 0.05）. There were no space-time pattern characteristics with neutral pictures. Amplitude of negative pictures was relatively higher, it had moderate-high excitement with middle and right cortex of frontal, partial, temporal and occipital lobe in spatial effect （P 〈 0.05）. In experimental group, amplitude of positive pictures decreased, and it was moderate excitatory with middle cortex of frontal, partial, temporal and occipital lobe （P 〈 0.05）; There was no space-time pattern characteristics with neutral pictures; the amplitude of negative pictures increased, and it had high excitement with middle and left cortex of frontal, partial, temporal and occipital lobe in spatial effect （P 〈 0.05）.Conclusion： Persistent somatoform pain disorder patients was disorganized in the ability to regulate and control emotion with frontal lobe, and thus we can take applying IAPS-ERP to the emotion detect of PSPD into consideration.

关 键 词：持续性躯体形式疼痛障碍 事件相关电位 情绪 

分 类 号：R749[医药卫生—神经病学与精神病学]