IL-10和CD14及CD68在喉鳞状细胞癌中的表达及相关性研究  

The expressions and correlations of IL-10,CD14 and CD68 in laryngal squamous cell carcinoma

作　　者：张森[1] 皇甫辉[1] 王斌全[1] 高伟[1] 武丽娜[2] 李莹[1] 李伟艳[1] 

机构地区：[1]山西医科大学第一医院耳鼻咽喉头颈外科耳鼻咽喉头颈肿瘤山西省重点实验室山西医科大学耳鼻咽喉研究所,太原030001 [2]山西医科大学第一医院病理科

出　　处：《临床耳鼻咽喉头颈外科杂志》2017年第11期839-843,共5页Journal of Clinical Otorhinolaryngology Head And Neck Surgery

基　　金：山西省青年科技研究基金项目(No:201601D021140)

摘　　要：目的:研究喉鳞状细胞癌组织IL-10及单核细胞、肿瘤相关巨噬细胞在肿瘤微环境中的分布情况。方法:采用免疫组织化学方法对IL-10、CD14、CD68在46例喉鳞状细胞癌组织中的表达进行研究,并探讨三者与临床病理参数之间的关系。结果:喉鳞状细胞癌组织中IL-10、CD14、CD68的表达与临床分期、T分期明显相关(均P<0.01),IL-10、CD14与淋巴结转移均有关(均P<0.01),CD68与病理分化程度相关(P<0.05)。IL-10和CD14在喉鳞状细胞癌组织中的表达呈正相关(P<0.01)。结论:喉鳞状细胞癌组织中IL-10、单核细胞、肿瘤相关巨噬细胞的浸润程度与肿瘤的进展程度相关,IL-10的表达与单核细胞有一定关系。Objective ：The aim of this study is to investigate the distribution of IL-10, CD14 and CD68 in the tumor microenvironment of LSCC with the clinicopathologic factors. Method：We detected the expressions of IL-10, CD14 and CD68 in 46 primary LSCC tumor tissues by immunohistochemistry staining and explore the relationship between them and clinicopathologic factors. Result：We found that the expressions of IL-10, CD14 and CD68 were significantly correlated with clinical stage and T stage（P〈0.01）. IL-10 and CD14 were correlated with lymph node metastasis（P〈0.01）, and CD68 was correlated with pathological differentiation（P〈0.05）. There is a posi- tive correlation trend between the expression of IL-10 and CD14（P〈0.01）. Conclusion： We confirm that the high level expressions of IL-10, monocytes and TAMs contribute to the tumor development of LSCC and there is a pos- itive correlation between the expression of IL-10 and monocytes.

关 键 词：喉肿瘤 鳞状细胞癌 IL-10 CD14 CD68 免疫组织化学 

分 类 号：R739.65[医药卫生—肿瘤]