ING5抑癌作用机制研究新进展  

Recent Advances in the Mechanism of ING5 Tumor Suppressor

作　　者：刘承波[1,2] 杨琳娜[2] 杨德红[2] 宿凌云[2] 邹莉[2] 冯云[2] 

机构地区：[1]昆明理工大学附属医院,昆明市650500 [2]云南省第一人民医院生殖妇科,昆明市650100

出　　处：《医学分子生物学杂志》2017年第2期121-124,共4页Journal of Medical Molecular Biology

基　　金：云南省卫生科技计划项目（NO.2014NS234,2014NS233,2014NS365,2014NS366）

摘　　要：肿瘤的发生是个涉及多基因改变的复杂过程,其中癌基因的激活和抑癌基因的失活是两大关键要素.生长抑制因子（inhibitor of growth,ING）作为候选抑癌基因家族,在肿瘤的发生、发展中起到重要的抑制作用.ING5是最新发现的生长抑制因子家族成员,研究结果表明ING5与P53相互作用并促进P53转录活化,从而引起细胞周期阻滞和凋亡.同时ING5是两种组蛋白乙酰基转移酶复合体的本结构,参与染色质重构的过程.它作为组蛋白和组蛋白乙酰基转移酶（histone acetyltransferase,HAT）之间的桥梁分子,可能通过调控基因的表达而发挥抑癌作用.文章将对ING5的抑癌作用机制作一综述.The occurrence of tumor is a complex process involving multiple gene changes, including activation of oncogenes and inactivation of tumor suppressor genes, which are the two key factors. Inhibitor of growth （ING） is a candidate tumor suppressor gene family, which plays an important role in the occurrence and development of tumor. ING5 is a member of the newly discovered growth inhibitor family. The results show that ING5 interacts with P53 and promotes P53 transcription activation, which can lead to cell cycle arrest and apoptosis. At the same time ING5 is the structure of the two histone acetyltransferase complex, which is involved in chromatin remodeling. It serves as a bridge between histone and histone acetyl transferase （ Histone acetyltransferase. HAT） .

关 键 词：肿瘤 ING5 P53 抑癌机制 

分 类 号：R394.7[医药卫生—医学遗传学]