中国地鼠线粒体基因组与微卫星遗传标记的研究  

Study of mitochondrial genomes and molecular genetic marker of microsatellite in chinese hamster

作　　者：宋国华[1] 陈朝阳[1] 刘田福[1] 庞文彪[1] 高继萍[1] 张锐虎[1] 刘茂林[1] 樊林花[1] 

机构地区：[1]山西医科大学实验动物中心,实验动物与人类疾病动物模型山西省重点实验室,太原030001

出　　处：《中国比较医学杂志》2017年第5期4-5,15,共3页Chinese Journal of Comparative Medicine

基　　金：山西省实验动物专项资金(2005k01,2009k02)

摘　　要：中国地鼠在生物医学研究中占有重要的地位,但中国地鼠的分子遗传标记研究尚少。本研究运用生物信息学和比较基因组学等方法分析了中国地鼠的线粒体基因组的碱基组成、基因组结构、基因进化等特征,为中国地鼠应用于人类疾病动物模型提供基因组数据。建立了中国地鼠近交系遗传质量控制体系,为中国地鼠种质资源科学评估、合理开发利用奠定了基础。Chinese hamster is an important laboratory animal in medical and biological researches,but the molecular genetic markers research was rarely reported.In our study the base composition,gene structure,genetic evolution and other characteristics of mitochondrial genome of Chinese hamster were analyzed using the methods of bioinformatics and comparative genomics,genetic quality detection system of Chinese hamster were also established.These results would supply genome data for animal models of human diseases,and lay the foundation for scientific evaluation and reasonable utilization.

关 键 词：中国地鼠 线粒体基因组 分子进化 微卫星 遗传检测 

分 类 号：R-33[医药卫生]