丙戊酸钠预防脑出血后癫痫发作的疗效评价  

Effect evaluation on sodium valproate in prevention of post-encephalorrhagia epileptic seizure

作　　者：杨小兰[1] 刘明龙[1] 陈杰[1] 杨明兵 宋跃[1] 魏东[1] 

机构地区：[1]四川省乐至县人民医院内四科,四川乐至641500

出　　处：《中国现代医生》2017年第15期34-36,共3页China Modern Doctor

摘　　要：目的探讨丙戊酸钠预防脑出血后癫痫发作的临床疗效及安全性。方法选取2013年9月~2016年12月我院收治的82例急性脑出血患者为研究对象,采用随机数字表法分组,对照组41例采用常规脑出血内科治疗方案,研究组41例在对照组基础上加用丙戊酸钠治疗,两组患者均连续用药14 d,随访观察2个月,对比两组患者的临床疗效、癫痫发生率及治疗期间的不良反应情况。结果研究组总有效率为85.4%(35/41),对照组总有效率为87.8%(36/41),两组对比无显著差异(P>0.05);研究组随访期间发生癫痫4例,其中强直阵挛发作2例,单纯部分性发作1例,失神发作1例,发生率为9.8%,对照组随访期间发生癫痫11例,其中强直阵挛发作4例,单纯部分性发作3例,复杂部分性发作2例,肌阵挛发作1例,失神发作1例,发生率为26.8%,两组差异具有统计学意义(P<0.05);研究组不良反应发生率为9.8%(4/41),对照组不良反应发生率为7.3%(3/41),两组比较无显著差异(P>0.05)。结论丙戊酸钠预防脑出血后癫痫发作的疗效确切,且安全性较好,值得在临床上推广和应用。Objective To investigate the effect and safety of sodium valproate in prevention of post-encephalorrhagia epileptic seizure. Methods 82 patients with acute encephalorrhagia treated in our hospital from September 2013 to December 2016 were selected and divided into two groups according random number table, 41 patients in the control group were given routine therapy against encephalorrhagia, and 41 patients in the study group were additionally given sodium valproate on the basis of control group, the treatment both for 14 d, and the patients were followed up for 2 months. The clinical effect, incidence rate of epilepsy and incidence of adverse events were compared between two groups. Resuits The overall response rate in the study group was 85.4%（35/41）, and that in the control group was 87.8%（36/41）, the difference was no statistically significant（P〉0.05）. There were 4 cases（9.8%） of epilepsy in the study group, of which 2 cases were tonic-clonic seizure, lcase was simple partial seizure, and 1 case was absence seizure. There were 11 cases （26.8%） of epilepsy in the control group, of which 4 cases were tonic-clonic seizure, 3 cases were simple partial seizure, 2 cases were complex partial seizure, 1 case was myoclonic seizure, and 1 case was absence seizure, the dif- ference was statistically significant between two groups（P〈0.05）. The incidence rate of complications was 9.8% （4/4!） in the study group, and that was 7.3%（3/41） in the control group, the difference was statistically significant（P〉0.05）. Conclusion The effect of sodium valproate in prevention of post-encephalorrhagia epileptic seizure is definite with good safety, which is ＂worthy to be promoted and applied in clinical.

关 键 词：脑出血 癫痫 丙戊酸钠 预防性用药 

分 类 号：R742.1[医药卫生—神经病学与精神病学]