OLC1在肺鳞癌组织中的过表达与患者的不良预后相关  

Overexpression of OLC1 in Lung Squamous Cell Carcinoma Tissues is Associated with Poor Prognosis of Patients

作　　者：张坤鹏[1] 赵格非[1] 肖汀[1] 李萍[1] 宋杰[1] 高燕宁[1] 孙克林[1] 

机构地区：[1]国家癌症中心/中国医学科学院北京协和医学院肿瘤医院,分子肿瘤学国家重点实验室癌发生与预防分子机理北京市重点实验室,北京100021

出　　处：《中国肺癌杂志》2017年第5期346-351,共6页Chinese Journal of Lung Cancer

基　　金：中国医学科学院医学与健康科技创新工程项目(No.2016-I2M-1-001)资助~~

摘　　要：背景与目的 OLC1(overexpressed in lung cancer 1)是本实验室前期工作中筛选克隆出的一个新型肺癌相关基因。它在肺癌和其它恶性肿瘤中均有较高表达,并与食管鳞癌、卵巢癌、乳腺癌、结直肠癌患者的不良预后相关。本研究旨在检测OLC1在肺鳞癌(squamous cell carcinoma,SCC)和腺癌(adenocarcinoma,ADC)患者肿瘤组织中的表达情况,研究其与肺癌患者预后之间的关系。方法分别对108例肺鳞癌和90例肺腺癌的癌组织进行免疫组织化学染色,检测OLC1蛋白的表达水平,分析OLC1的表达水平与临床特征及预后的关系。结果 OLC1在肺腺癌组织中的过表达率显著高于鳞癌(87.5%vs 55.3%,P<0.001)。OLC1在癌组织中的过表达与肺腺癌患者的预后无显著相关性,与肺鳞癌患者的预后关系的单因素分析显示两者存在相关性(P=0.042),而多因素分析则显示OLC1过表达与鳞癌患者预后的相关性无统计学意义(P=0.05)。结论 OLC1在肺腺癌组织中的过表达高于鳞癌,在癌组织中的过表达仅与鳞癌患者的不良预后相关,但不能作为影响预后的独立危险因素。Background and objective OLC1 （overexpressed in lung cancer 1）, screened out and cloned in our previous research, is a new gene associated with lung cancer. It is highly expressed in lung cancer and many other malignant tu- mors, and is associated with poor prognosis of esophageal squamous cell carcinoma, ovarian cancer, breast cancer and colorec- tal cancer. The aim of this research was to detect the expression level of OLC 1 in the tumor tissues of lung adenocarcinoma （ADC） and squamous cell carcinoma （SCC） and explore its relationship with the prognosis of lung cancer patients. Methods Lung cancer tissues of 108 SCC and 90 ADC was dealed with immunohistochemical staining to detect the expression level of OLC1. ＂lhe relationship between the expression level of OLC1 and clinical parameters and prognosis was analyzed. Results The rate of high expression of OLC1 staining in ADC was significantly higher than that in SCC （87.5% vs 55.3%, P〈0.001）. The overexpression of OLC1 in tumor tissues did not have a significant relationship with the prognosis of patients with ADC, but it was related with a poor prognosis of SCC patients as the univariate analysis showed. However the multivariate regression analysis showed that correlation between the overexpression of OLC1 and poor prognosis of SCC patients did not have a statis- tical significance （P=0.0S）. Conclusion The expression of OLC1 in ADC might be higher than that in SCC. A higher score of OLC 1 staining in tumor tissue was associated with a poorer prognosis of patients with SCC, but could not be an independent predictor for a shorter overall survival in patients with SCC.

关 键 词：OLC1 免疫组织化学 肺鳞癌 预后 

分 类 号：R734.2[医药卫生—肿瘤]