疏肝解毒汤联合CHOP化疗方案治疗恶性淋巴瘤疗效观察  

Effect of Shugan Jiedu Decoction combined with CHOP chemotherapy regimen in the treatment of malignant lymphoma

作　　者：柯珂[1] 余云熹 

机构地区：[1]鄂东医疗集团黄石市中心医院(湖北省理工学院附属医院),湖北黄石435000 [2]鄂东医疗集团黄石市中医院团城山院区,湖北黄石435000

出　　处：《现代中西医结合杂志》2017年第18期1955-1958,共4页Modern Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的观察CHOP化疗方案联合疏肝解毒汤治疗恶性淋巴瘤的临床疗效。方法将80例中度非霍奇金淋巴瘤患者随机分为2组,对照组给予CHOP化疗方案,观察组在对照组治疗基础上加用中药疏肝解毒汤治疗。观察2组临床疗效,治疗前后KPS评分、QOL评分及CD3^+、CD4^+、CD8^+、CD4^+/CD8^+变化情况,统计2组不良反应发生情况。结果 2组治疗有效率与疾病控制率比较差异均无统计学意义(P均>0.05)。治疗后对照组KPS评分明显降低(P<0.05),观察组无明显变化(P>0.05);观察组QOL评分明显升高(P<0.05),对照组无明显变化(P>0.05)。治疗后观察组CD3^+、CD4^+、CD8^+、CD4^+/CD8^+均无明显改变(P均>0.05),对照组CD3^+、CD4^+、CD4^+/CD8^+均比治疗前明显降低(P均<0.05),CD8^+比治疗前明显升高(P<0.05),观察组CD3^+、CD4^+、CD4^+/CD8^+均明显高于对照组(P均<0.05),CD8^+明显低于对照组(P<0.05)。观察组白细胞降低、神经毒性、恶心呕吐、肝肾功能异常发生率均明显低于对照组(P均<0.05)。结论疏肝解毒汤联合CHOP化疗方案治疗恶性淋巴瘤效果较好,可以有效增强患者机体细胞免疫功能,改善患者体力与生存质量,减轻毒副作用。Objective It is to observe the clinical curative effect of CHOP chemotherapy combined with Shugan Jiedu Decoction （SGJDD） in the treatment of malignant lymphoma. Methods 80 patients with midrange non Hodgkin＇ s lymphoma were randomly divided into two groups, 40 cases in the control group was given treatment for CHOP chemotherapy regimen, and the other 40 cases in the observation group were treated with traditional Chinese drug SGJDD on the basis of the treatment of the control group. The clinical curative effect of the 2 groups was observed, the scores of KPS, QOL, CD3 ＋ , CD4 ＋ , CD8 ＋ were measured before and after treatment, and the incidence of adverse reactions in the 2 groups was statistically ana- lyzed. Results There was no significant difference between the two groups in the treatment effective rate and the disease control rate （ all P 〉 0.05）. After treatment, the KPS score of the control group was significantly decreased （P 〈 0. 05 ） , but there was no obvious change in the observation group （P 〉0O. 05） ; the QOL score of the observation group was increased obviously （ P 〈 0.05）, but there was no obvious change in the control group （P 〉 0.05 ）. After treatment, there were no obvious chan- ges in CD3 ＋, CD4 ＋, CD8 ＋ and CD4 ＋/CD8 ＋ in the observation group （all P〉0.05）, the levels of CD3＋, CD4 ＋ and CD4 ＋/CD8 ＋ in the control group were significantly decreased and CD8 ＋ was significantly increased than those before treat- ment （all P 〈0.05） , the levels of CD3 ＋ , CD4 ＋ and CD4 ＋/CD8 ＋ in the observation group were significantly higher and CD8 ＋ was significantly lower than those in the control group （ all P 〈 0.05）. The incidence of WBC decrease, neurotoxicity, nausea and vomiting, abnormal liver and kidney function in the observation group were significantly lower than those in the control group （ all P 〈 0.05）. Conclusion SGJDD combined with CHOP chemotherapy is effective in the treatment of malig- nant ly

关 键 词：疏肝解毒汤 CHOP化疗 恶性淋巴瘤 

分 类 号：R733.4[医药卫生—肿瘤]