阿司匹林、氯吡格雷双抗血小板对动脉粥样硬化致脑血管狭窄的影响  

Effect of aspirin and clopidogrel dual antiplatelet therapy on cerebral vascular stenosis caused by atherosclerosis

作　　者：龚煜[1] 温丹[1] 宋治洁[1] 王兵[1] 

机构地区：[1]广东省东莞市黄江医院,广东东莞523750

出　　处：《中国医药科学》2017年第8期43-45,共3页China Medicine And Pharmacy

基　　金：广东省东莞市医疗卫生科技计划一般项目(2015105101149)

摘　　要：目的探讨联合使用阿司匹林、氯吡格雷双抗血小板治疗对动脉粥样硬化(AS)致脑血管狭窄的影响。方法将我院2013年4月~2016年5月期间诊治的AS致脑血管狭窄并行DSA的62例患者随机分为治疗组(n=31)和对照组(n=31),治疗组使用阿司匹林联合氯吡格雷治疗90d,对照组使用阿司匹林治疗90d,比较两组患者治疗前后平均动脉狭窄率和终点事件发生时间。结果治疗组患者治疗90d后平均动脉狭窄率显著低于对照组(P<0.05),终点事件发生时间显著晚于对照组,差异具有统计学意义(P<0.05)。结论阿司匹林、氯吡格雷双抗血小板治疗可以有效减轻AS患者脑血管狭窄程度,降低血管内介入治疗可能,安全性高,值得广泛推广。Objective To explore the effect Of aspirin and clopidogrel dual antiplatelet therapy on cerebral vascular stenosis caused by atherosclerosis （AS）： Methods 62 cases of patients with cerebral vascular stenosis caused by AS treated in our hospital from April 2013 to May 2016 were divided into the treatment group （n=31） and the control group （n=31）. The treatment group received 90 days of treatment with aspirin combined with clopidogrel, while the control group received 90 days of treatment with aspirin alone. The mean arterial stenosis rate and the end point between the two groups were compared. Results After 90 days of treatment, the mean arterial stenosis rate in the treatment group was significantly lower than that in the control group （P 〈 0.05）. The incidence of the end point was significantly lower than that of the control group, the difference was statistically significant （P 〈 0.05）. Conclusion Dua! antiplatelet therapy with aspirin and clopidogrel can effectively reduce the degree of cerebral vascular stenosis in patients caused by AS, and reduce the possibility of endovascular interventional therapy. It has high safety.

关 键 词：阿司匹林 氯吡格雷 抗血小板 动脉粥样硬化 脑血管狭窄 

分 类 号：R743.33[医药卫生—神经病学与精神病学]