颌骨骨肉瘤3例临床病理观察  

Osteosarcoma of the jaws:a clinicopathological analysis of three cases

作　　者：徐方平[1] 骆新兰[1] 梅平[1] 颜黎栩[1] 刘超[1] 刘艳辉[1] 

机构地区：[1]广东省人民医院广东省医学科学院病理医学部病理科,广州510080

出　　处：《诊断病理学杂志》2017年第5期346-349,共4页Chinese Journal of Diagnostic Pathology

摘　　要：目的本文报告3例罕见的颌骨骨肉瘤并加以讨论。方法回顾性分析近3年来发现的3例颌骨骨肉瘤,探讨其临床、影像学、病理形态学、免疫组化及分子病理学特征,并结合文献资料讨论相关的鉴别诊断。结果3例颌骨骨肉瘤患者年龄分别为49岁、46岁和51岁,其中2例肿瘤位于左上颌骨,1例位于右上颌骨。病理诊断均为颌骨骨肉瘤,其中1例为继发性。结论颌骨骨肉瘤的发病年龄、临床特征及形态学特点均与四肢长骨骨肉瘤有所不同;临床、影像、病理的综合分析,并辅以必要的免疫组化检测可及时诊断。Objective To report three cases of rare osteosarcoma of the jaws. Methods A retrospective clinicopathological study was made on three cases of osteosarcoma of the jaws in past three years in our hospital. The clinical characteristics, radiological appearance, pathological, immunohistochemical and molecular pathological findings were analyzed, and also the literatures were reviewed. Results Three cases of osteosarcoma of the jaws occurred in patients at the age of 49 years, 46 years and 51 years, respectively, and two of the tumors located in the left maxilla and one in right maxilla. All the pathological diagnoses were osteosarcoma of maxilla, and one case was secondary osteosarcoma. Conclusion There are some differences including age of onset, clinical features and morphological characteristics between osteosareoma of the jaws and ordinary osteosarcoma of long bones. Intergrative analysis of clinical, radiology and pathological findings and application of some necessary ancillary techniques such as immuuohistochemistry will help inaccuracy and timely diagnosis of such rare osteosarcoma of the jaws.

关 键 词：颌骨骨肉瘤 临床病理 分子病理 

分 类 号：R739.82[医药卫生—肿瘤]