拉坦前列素对高眼压症、开角性青光眼的疗效及安全性分析  

Efficacy and safety analysis of the latanoprost on decreasing intraocular pressure in ocular hypertension and open angle glaucoma

作　　者：黎锦萍 曹征 周沛辉 陈硕 郭娴吟 杨杰凤 LI Jin-ping CAO Zheng ZHOU Pei-hui CHEN Shuo GUO Xian-yin YANG Jie-feng(Department of Ophthalmology, The Third People＇s Hospital of Dongguan, Dongguan Guangdong 523326, Chin)

机构地区：[1]广东省东莞市第三人民医院眼科,523326

出　　处：《蚌埠医学院学报》2017年第3期326-328,331,共4页Journal of Bengbu Medical College

摘　　要：目的:探讨拉坦前列素治疗高眼压症、开角性青光眼(POAG)的临床疗效及安全性。方法:采用随机单盲对照实验,将80例(80眼)高眼压症或POAG病人随机分为观察组和对照组各40例(40眼),观察组应用拉坦前列素滴眼液,对照组采用曲伏前列素滴眼液治疗,均为1次/天,连续用药4周,观察2组临床疗效。结果:2组治疗前和治疗后第1、2、3、4周的眼压差异均无统计学意义(P>0.05),2组病人治疗后1、2、3、4周的眼压均较治疗前显著降低(P<0.01)。治疗后,2组病人的上午8时、11时和下午2时、下午4时的眼压均较治疗前显著降低(P<0.01),2组病人治疗前和治疗后的上午8时、11时和下午2时、4时的眼压比较差异均无统计学意义(P>0.05)。治疗前2组病人的视野平均缺损、中央角膜厚度、Schirmer、BUT实验和治疗后BUT实验结果差异均无统计学意义(P>0.05);观察组治疗后视野平均缺损、Schirmer实验结果均低于对照组(P<0.01和P<0.05),而中央角膜厚度大于对照组(P<0.01)。2组病人治疗期间结膜充血、眼痒、眼痛和灼烧感的发生率差异均无统计学意义(P>0.05)。结论:拉坦前列素与曲伏前列素治疗高眼压症、POAG病人均能取得较好的效果,不良反应率相当。Objective：To investigate the efficacy and safety of the latanoprost in the treatment of ocular hypertension and open angle glaucoma（ POAG）. Methods：Using a randomized single blind controlled trial,80 patients（ 80 eyes） with ocular hypertension or POAG were randomly divided into the observation group and control group （40 cases each group ）. The observation group and control group were treated with latanoprost and travoprost, once a day, for 4 weeks, respectively. The clinical efficacy in 2 groups were observed. Results：The differences of intraocular pressure（IOP） before treatment and after 1,2,3 and 4 weeks of treatment between two groups were not statistically significant （ P 〉 0.05 ）. Compared with before treatment, the lOP in 2 groups after 1,2,3 and 4 weeks of treatment significantly decreased （P 〈 0.01 ）. Compared with before treatment, the IOP in 2 groups at 8 and 11 o＇clock in the morning, and 2 and 4 o＇clock in the afternoon significantly decreased after treatment（P 〈0.01 ） ,and the differences of the IOP in 2 groups at 8 and 11 o＇ clock in the morning, and 2 and 4 o＇ clock between before and after treatment were not statistically significant （ P 〉 0.05 ）. The differences of the mean defect of visual field, central corneal thickness and Schirmer value before treatment, and BUT value before and after treatment between two groups were not statistically significant （ P 〉 0.05 ）. After treatment, the mean defect of visual field and Schirmer value in observation group were lower than that in control group （P 〈 0.05 and P 〈 0.01 ） , and the central corneal thickness in observation group was higher than that in control group（ P 〈 0.01 ）. During the treatment, the differences of the incidence rate of the conjunctival congestion, ngeyan, eye pain and burning sensation between two groups were not statistically significant （ P 〉 0.05 ）. Conclusions：The effects of latanoprost and travoprost in the treatment of ocular hypertension and PO

关 键 词：青光眼 拉坦前列素 高眼压症 安全性 

分 类 号：R775[医药卫生—眼科]