肺移植后闭塞性细支气管炎动物模型  

A review for animal models of obliterative bronchiolitis after lung transplantation

作　　者：徐凯英 王思桦[1] 王建军[1] 

机构地区：[1]华中科技大学同济医学院附属协和医院胸外科,武汉430022

出　　处：《中华移植杂志（电子版）》2017年第1期59-64,共6页Chinese Journal of Transplantation(Electronic Edition)

基　　金：国家自然科学基金青年基金项目(81401323)

摘　　要：肺移植已经成为终末期良性肺部疾病的重要治疗方法。随着手术技术、围手术期管理及免疫抑制治疗的发展,肺移植后早期生存率明显提高,但长期生存率却无显著改善。闭塞性细支气管炎(OB)是影响肺移植后长期生存的主要因素。基于动物模型的研究对于我们探索OB发生的病理机制以及研发新的防治措施都是必不可少的。目前,已经建立了许多用于OB研究的动物模型。本文对目前用于OB研究的各种动物模型的优缺点展开综述,期望帮助研究人员选择合适的动物模型。Lung transplantation has become an important therapy for patients with end-stage benign lung disease. With the progress of surgical technique, perioperative mananment and immunosuppressive therapy, surival rate in early stage after transplant have significantly improved, while long-term surival rate has not changed much. 0bliterative bronchiolitis （0B） is the major limitation to long-term surival after lung transplatation. Ivestigation basing on animal models is indispensable to understand the underlying pathological mechanisms and to develop novel preventive and therapetic stragies for 0B. So far, many animal models have been developed to study 0B. This article reviews the strengths and drawbacks of those animal models, hoping to help researchers in chooseing the appropriate model for their intrended research.

关 键 词：肺移植 动物模型 闭塞性细支气管炎 慢性排斥反应 

分 类 号：R-332[医药卫生] R655.3