“功能性肠病”的器质性病因  

Functional Bowel Disorders,Are They Really Functional?

作　　者：左秀丽[1] ZUO Xiuli(Department of Gastroenterology, Qilu Hospital of Shandong University, Jinan （ 250012)

机构地区：[1]山东大学齐鲁医院消化内科,250012

出　　处：《胃肠病学》2017年第5期257-261,共5页Chinese Journal of Gastroenterology

摘　　要：功能性肠病(FBD)被定义为有肠道感觉、分泌、运动功能失调的临床表现但无组织结构和(或)血液生化异常的一组肠道疾病。FBD的发病机制至今仍不十分清楚,所谓的"功能性"是否是由于当前医学发展不足或是因为现有检查技术的局限性仍然未知。随着生物医学技术的进步,一些显微镜下的组织学或生化改变在部分FBD中被发现,为FBD可能存在"器质性异常"提供了支持证据。本文着重讨论肠易激综合征和功能性便秘中"器质性"改变的研究进展。Functional bowel disorders （FBD） refer to a set of bowel symptoms related to the disorders of sensation, secretion and motility yet without a corresponding structural, histological, biochemical, or serological abnormalities.The pathogensesis of FBD is still not very clear.Whether these functional disorders reflect the inadequacy of our understanding of a disease or the limitation of our diagnostic testing is a question.With the development of the biomedical technology, some histological or biochemical changes were revealed, which supported the possibility that organic abnormality might exist in FBD.In this paper the progress of research on organic changes of irritable bowel syndrome and functional constipation was reviewed.

关 键 词：功能性肠病 肠易激综合征 便秘 炎症 肠屏障 

分 类 号：R574[医药卫生—消化系统]